Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21170370 | 0.80 | MET (0.36) | METSLC6A2SLC6A4SLC6A3P2RX7 | |
| Acetic Acid SCHEMBL4631502 | 0.80 | PARP1 (0.47) | ALDH1A1HPGDSFYNMAP2K4KDM1A | |
| SCHEMBL29431721 | 0.76 | HSD17B1 (0.53) | FYNKDM1A | |
| SCHEMBL24359756 | 0.75 | RAB9A (0.49) | SLC6A2SLC6A4SLC6A3ALDH1A1MAPT | |
| SCHEMBL5563045 | 0.75 | GABRG2 (0.56) | KDM4E | |
| SCHEMBL27597148 | 0.73 | ERCC5 (0.47) | METP2RX7ALDH1A1MAPTKDM4E | |
| SCHEMBL2615353 | 0.73 | MAOB (0.46) | MAPT | |
| SCHEMBL13745012 | 0.73 | MET (0.52) | METALDH1A1MAPTHPGDSKDM4E | |
| SCHEMBL21780810 | 0.72 | HDAC4 (0.42) | METPRSS1PRSS2PRSS3HPGDS | |
| SCHEMBL21170354 | 0.72 | PSEN1 (0.37) | PRSS1PRSS2PRSS3ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127541-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2019-07-17 | — | — | EP | disclosed |