Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS2 | Q07890 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 5/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 2/20 | 0.35 |
| ▸ | CASP7 | P55210 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2115464 | 0.84 | SOS2 (0.43) | SOS2PIM1ALOX15SRCMCL1 | |
| SCHEMBL2118311 | 0.84 | PIM1 (0.46) | SOS2PIM1ALOX15SRCMCL1 | |
| SCHEMBL13689572 | 0.79 | NCF1 (0.39) | PIM1ALOX15KDM4EGAAMEN1 | |
| SCHEMBL2116276 | 0.79 | CTSB (0.43) | SOS2PIM1KDM4EMEN1ALDH1A1 | |
| SCHEMBL2116537 | 0.77 | PIM1 (0.50) | SOS2PIM1MCL1KDM4EGAA | |
| SCHEMBL2116777 | 0.76 | ALOX15 (0.49) | SOS2ALOX15SRCMEN1ALDH1A1 | |
| SCHEMBL2118893 | 0.75 | FDPS (0.52) | ALOX15MCL1KDM4EMEN1ALDH1A1 | |
| SCHEMBL2116734 | 0.74 | FDPS (0.51) | ALOX15MCL1KDM4EMEN1ALDH1A1 | |
| SCHEMBL2116297 | 0.74 | GPR84 (0.35) | MCL1KDM4EGAAMEN1ALDH1A1 | |
| Lithium SCHEMBL2116737 | 0.74 | FDPS (0.51) | ALOX15MCL1KDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120094958-A1 | QUINOLINES AS INHIBITORS OF FARNESYL PYROPHOSPHATE SYNTHASE | NOVARTIS AG (CH) | 2012-04-19 | — | — | US | disclosed |
| CN-101959865-A | Quinolines as farnesyl pyrophosphate synthase inhibitor | NOVARTIS AG | 2011-01-26 | — | — | CN | disclosed |
| EP-2250152-A1 | QUINOLINES AS INHIBITORS OF FARNESYL PYROPHOSPHATE SYNTHASE | Novartis AG (CH) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009106586-A1 | QUINOLINES AS INHIBITORS OF FARNESYL PYROPHOSPHATE SYNTHASE | NOVARTIS AG (CH) | 2009-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094958-A1 | QUINOLINES AS INHIBITORS OF FARNESYL PYROPHOSPHATE SYNTHASE | FDPS, GGPS1, CTPS1 | SOS2 1622/4885PIM1 2265/4885ALOX15 1414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.