Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 9/20 | 0.36 |
| ▸ | CA1 | P00915 | 8/20 | 0.36 |
| ▸ | CA9 | Q16790 | 7/20 | 0.36 |
| ▸ | CA12 | O43570 | 3/20 | 0.36 |
| ▸ | CA7 | P43166 | 3/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.36 |
| ▸ | CA3 | P07451 | 2/20 | 0.36 |
| ▸ | CA4 | P22748 | 2/20 | 0.36 |
| ▸ | CA6 | P23280 | 2/20 | 0.36 |
| ▸ | CA5A | P35218 | 2/20 | 0.36 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.36 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.35 |
| ▸ | RECQL | P46063 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21178108 | 1.00 | SPHK1 (0.37) | SPHK1CA2CA1CA9CA12 | |
| SCHEMBL22801258 | 1.00 | SPHK1 (0.37) | SPHK1CA2CA1CA9CA12 | |
| SCHEMBL18817977 | 1.00 | SPHK1 (0.37) | SPHK1CA2CA1CA9CA12 | |
| SCHEMBL21178189 | 0.98 | CA1 (0.34) | SPHK1CA2CA1CA9CA12 | |
| SCHEMBL4342842 | 0.91 | ADRB2 (0.33) | CA2CA1TSHR | |
| SCHEMBL31465154 | 0.83 | SPHK1 (0.37) | SPHK1CA2CA1CA9CA12 | |
| SCHEMBL31465159 | 0.83 | SPHK1 (0.37) | SPHK1CA2CA1CA9CA12 | |
| SCHEMBL20709888 | 0.83 | SPHK1 (0.37) | SPHK1CA2CA1CA9CA12 | |
| SCHEMBL31465182 | 0.83 | SPHK1 (0.37) | SPHK1CA2CA1CA9CA12 | |
| SCHEMBL17445651 | 0.82 | SPHK1 (0.36) | SPHK1CA2CA1CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240294565-A1 | UNNATURAL CONFIGURATION NUCLEOTIDE PRODRUG COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED | 2024-09-05 | — | — | US | disclosed |
| WO-2022245584-A1 | UNNATURAL CONFIGURATION NUCLEOTIDE PRODRUG COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2022-11-24 | — | — | WO | disclosed |
| US-11427550-B2 | 5-fluorouracil compounds | NUCORION PHARMACEUTICALS, INC. (US) | 2022-08-30 | — | — | US | disclosed |
| US-20200399227-A1 | 5-FLUOROURACIL COMPOUNDS | NUCORION PHARMACEUTICALS, INC. | 2020-12-24 | — | — | US | disclosed |
| WO-2019143860-A1 | 5-FLUOROURACIL COMPOUNDS | NUCORION PHARMACEUTICALS, INC. (US) | 2019-07-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200399227-A1 | 5-FLUOROURACIL COMPOUNDS | DPYD, DHFR, FAU | SPHK1 3492/4885CA2 4877/4885CA1 4686/4885 |
| US-11427550-B2 | 5-fluorouracil compounds | DPYD, DHFR, MTHFD1 | SPHK1 3320/4885CA2 4877/4885CA1 4556/4885 |
| US-20240294565-A1 | UNNATURAL CONFIGURATION NUCLEOTIDE PRODRUG COMPOUNDS | PNP, NUDT1, ENTPD5 | SPHK1 288/4885CA2 3668/4885CA1 3853/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.