Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 7/20 | 0.38 |
| ▸ | HTR1D | P28221 | 7/20 | 0.38 |
| ▸ | HTR1B | P28222 | 7/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.37 |
| ▸ | HTR6 | P50406 | 3/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21179646 | 0.85 | OPRK1 (0.39) | OPRM1OPRK1OPRL1HTR6MEN1 | |
| SCHEMBL21179533 | 0.83 | HTR6 (0.42) | ADRB2HTR1AHTR1DHTR1BOPRM1 | |
| SCHEMBL20213221 | 0.80 | OPRL1 (0.66) | OPRM1OPRK1OPRL1 | |
| SCHEMBL20213224 | 0.80 | OPRL1 (0.66) | OPRM1OPRK1OPRL1 | |
| SCHEMBL30813307 | 0.80 | OPRL1 (0.66) | OPRM1OPRK1OPRL1 | |
| SCHEMBL21179650 | 0.72 | HTR6 (0.40) | OPRM1OPRK1OPRL1HTR6 | |
| SCHEMBL23034680 | 0.72 | OPRM1 (0.43) | OPRM1OPRK1OPRL1HTR6 | |
| SCHEMBL10716617 | 0.70 | MEN1 (0.42) | OPRM1OPRK1OPRL1MEN1KMT2A | |
| SCHEMBL20213038 | 0.69 | OPRL1 (0.71) | OPRM1OPRK1OPRL1 | |
| SCHEMBL20213039 | 0.69 | OPRL1 (0.71) | OPRM1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11827617-B2 | Piperidinyl nociceptin receptor compounds | ASTRAEA THERAPEUTICS, LLC (US) | 2023-11-28 | — | — | US | disclosed |
| US-20210053937-A1 | PIPERIDINYL NOCICEPTIN RECEPTOR COMPOUNDS | ASTRAEA THERAPEUTICS, LLC | 2021-02-25 | — | — | US | disclosed |
| US-10358432-B2 | Piperdinyl nociceptin receptor compounds | ASTRAEA THERAPEUTICS, LLC (US) | 2019-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11827617-B2 | Piperidinyl nociceptin receptor compounds | OPRL1, OPRK1, OPRM1 | ADRB2 292/4885CYP1A2 2641/4885CYP2C9 3488/4885 |
| US-20210053937-A1 | PIPERIDINYL NOCICEPTIN RECEPTOR COMPOUNDS | OPRL1, OPRK1, OPRM1 | ADRB2 292/4885CYP1A2 2641/4885CYP2C9 3488/4885 |
| US-10358432-B2 | Piperdinyl nociceptin receptor compounds | OPRL1, OPRK1, OPRD1 | ADRB2 281/4885CYP1A2 2809/4885CYP2C9 3444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.