Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.33 |
| ▸ | CHRNA1 known ✓ | P02708 | 1/20 | 0.32 |
| ▸ | CHRNG known ✓ | P07510 | 1/20 | 0.32 |
| ▸ | CHRNB1 known ✓ | P11230 | 1/20 | 0.32 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.32 |
| ▸ | CHRND known ✓ | Q07001 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | HTR7 | P34969 | 2/20 | 0.34 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5951962 | 0.89 | HPGD (0.33) | KDM1ASLC6A4MTNR1ADRD2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5952377 | 0.88 | HTR1A (0.30) | HTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL8604890 | 0.82 | SLC6A4 (0.36) | CNR1CNR2KDM1AHTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL2862429 | 0.82 | SLC6A4 (0.35) | CNR1CNR2KDM1AHTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL4068158 | 0.76 | ALDH1A1 (0.37) | CNR1CNR2KDM1ANISCHSLC6A4 | |
| Hydrochloric Acid SCHEMBL4094233 | 0.76 | ALDH1A1 (0.37) | CNR1CNR2KDM1ANISCHMTNR1A | |
| Hydrochloric Acid SCHEMBL5951783 | 0.75 | HTR7 (0.35) | KDM1AHTR1AHTR7NISCHSLC6A4 | |
| Hydrochloric Acid SCHEMBL650587 | 0.75 | ACHE (0.32) | — | |
| Hydrochloric Acid SCHEMBL651332 | 0.75 | ACHE (0.32) | — | |
| Hydrochloric Acid SCHEMBL8072623 | 0.75 | ALDH1A1 (0.36) | CNR1CNR2KDM1ANISCHMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8957159-B2 | Multiple catalyst system for olefin polymerization and polymers produced therefrom | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2015-02-17 | — | — | US | disclosed |
| US-20140066567-A1 | Multiple Catalyst System for Olefin Polymerization and Polymers Produced Therefrom | EXXONMOBIL CHEMICAL PATENTS INC. | 2014-03-06 | — | — | US | disclosed |
| US-8563647-B2 | Multiple catalyst system for olefin polymerization and polymers produced therefrom | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2013-10-22 | — | — | US | disclosed |
| US-20120095157-A1 | Multiple Catalyst System For Olefin Polymerization And Polymers Produced Therefrom | EXXONMOBIL CHEMICAL PATENTS INC. | 2012-04-19 | — | — | US | disclosed |
| US-8071687-B2 | Multiple catalyst system for olefin polymerization and polymers produced therefrom | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2011-12-06 | — | — | US | disclosed |
| US-20090069475-A1 | Multiple catalyst system for olefin polymerization and polymers produced therefrom | EXXONMOBIL CHEMICAL PATENTS INC. | 2009-03-12 | — | — | US | disclosed |
| US-20070293640-A1 | Multiple catalyst system for olefin polymerization and polymers produced therefrom | EXXONMOBIL CHEMICAL PATENTS INC. | 2007-12-20 | — | — | US | disclosed |
| US-7294681-B2 | Mutliple catalyst system for olefin polymerization and polymers produced therefrom | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2007-11-13 | — | — | US | disclosed |
| US-7223822-B2 | Multiple catalyst and reactor system for olefin polymerization and polymers produced therefrom | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2007-05-29 | — | — | US | disclosed |
| US-7037989-B2 | Copolymers of ethylene and/or α-olefins and vicinally disubstituted olefins | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2006-05-02 | — | — | US | disclosed |
| WO-2004106394-A1 | COPOLYMERS OF ETHYLENE AND/OR α-OLEFINS AND VICINALLY DISUBSTITUTED OLEFINS | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2004-12-09 | — | — | WO | disclosed |
| US-20040242814-A1 | COPOLYMERS OF ETHYLENE AND/OR ALPHA-OLEFINS AND VICINALLY DISUBSTITUTED OLEFINS | EXXONMOBIL CHEMICAL PATENTS INC. | 2004-12-02 | — | — | US | disclosed |
| US-20040220359-A1 | Multiple catalyst and reactor system for olefin polymerization and polymers produced therefrom | EXXONMOBIL CHEMICAL PATENTS INC. | 2004-11-04 | — | — | US | disclosed |
| US-20040138392-A1 | polyolefin adhesives; to produce reactor blends (also called intimate blends) of various polymers and other polymer compositions. | EXXONMOBIL CHEMICAL PATENTS INC. | 2004-07-15 | — | — | US | disclosed |
| US-6562918-B1 | A catalyst for olefin polymerization, which is obtained by contacting (A) a compound of a transition metal of Groups 4 to 6 of the Periodic Table, (B) an organoaluminiumoxy compound, and optionally (C) a carrier with each other, and for which | IDEMITSU PETROCHEMICAL CO., LTD. (JP) | 2003-05-13 | — | — | US | disclosed |
| US-6537478-B1 | Injection moulding articles made of metallocene polypropylene | BASELL POLYOLEFINE GMBH (DE) | 2003-03-25 | — | — | US | disclosed |
| EP-1085025-A1 | CATALYST FOR OLEFIN POLYMERIZATION, PROCESS FOR PRODUCING THE SAME, AND PROCESS FOR PRODUCING OLEFIN POLYMER | Idemitsu Petrochemical Co., Ltd. (JP) | 2001-03-21 | — | — | EP | disclosed |
| US-6184402-B1 | RESOLUTION OF A STEREOISOMERIC MIXTURE OF SPECIFIC METALLOCENE COMPLEXES BRIDGED WITH A TRANSITION METAL HAVING AN OXYGEN BOND ATTACHED, I.E., A MU-OXO COMPLEX; HYDROLYSIS IN THE PRESENCE OF A BASE; SEPARATION OF MESO FORM FROM MIXES | CHISSO CORPORATION (JP) | 2001-02-06 | — | — | US | disclosed |
| US-5770752-A | Process for reducing the concentration of by-products in product mixtures | TARGOR GMBH (DE) | 1998-06-23 | — | — | US | disclosed |