Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 10/20 | 0.98 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.98 |
| ▸ | MAPT | P10636 | 8/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.64 |
| ▸ | GAA | P10253 | 5/20 | 0.64 |
| ▸ | PKM | P14618 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 6/20 | 0.62 |
| ▸ | NPC1 | O15118 | 5/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | CLK1 | P49759 | 1/20 | 0.59 |
| ▸ | GSK3A | P49840 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23691177 | 0.82 | MAPT (0.69) | MEN1KMT2AMAPTALDH1A1TDP1 | |
| SCHEMBL12297320 | 0.78 | MEN1 (0.80) | MEN1KMT2AMAPTALDH1A1TDP1 | |
| SCHEMBL12297257 | 0.78 | VCP (0.68) | MEN1KMT2AMAPTALDH1A1TDP1 | |
| SCHEMBL12297791 | 0.77 | MEN1 (0.84) | MEN1KMT2AMAPTALDH1A1TDP1 | |
| SCHEMBL12297347 | 0.77 | PTGS2 (0.69) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL3606948 | 0.76 | KMT2A (0.61) | MEN1KMT2AMAPTALDH1A1TDP1 | |
| SCHEMBL1890978 | 0.76 | MEN1 (0.78) | MEN1KMT2AMAPTALDH1A1TDP1 | |
| SCHEMBL12297258 | 0.76 | MEN1 (0.67) | MEN1KMT2AMAPTALDH1A1TDP1 | |
| SCHEMBL23742591 | 0.76 | CYP1A2 (0.69) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL6155879 | 0.76 | MEN1 (0.67) | MEN1KMT2AMAPTALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230250086-A1 | METHIONINE METABOLIC PATHWAY INHIBITORS | MIGAL - GALILEE RESEARCH INSTITUTE LTD. (IL) | 2023-08-10 | — | — | US | disclosed |
| US-20230250086-A1 | METHIONINE METABOLIC PATHWAY INHIBITORS | MIGAL - GALILEE RESEARCH INSTITUTE LTD. (IL) | 2023-08-10 | — | — | US | disclosed |
| US-11639345-B2 | Methionine metabolic pathway inhibitors | MIGAL—GALILEE RESEARCH INSTITUTE LTD. (IL) | 2023-05-02 | — | — | US | disclosed |
| US-11639345-B2 | Methionine metabolic pathway inhibitors | MIGAL—GALILEE RESEARCH INSTITUTE LTD. (IL) | 2023-05-02 | — | — | US | disclosed |
| US-20200331872-A1 | METHIONINE METABOLIC PATHWAY INHIBITORS | MIGAL - GALILEE RESEARCH INSTITUTE LTD. (IL) | 2020-10-22 | — | — | US | disclosed |
| WO-2019142192-A1 | NEW METHIONINE METABOLIC PATHWAY INHIBITORS | GAVISH-GALILEE BIO APPLICATIONS LTD. (IL) | 2019-07-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11639345-B2 | Methionine metabolic pathway inhibitors | GSS, MTR, CTH | MEN1 1485/4885KMT2A 2664/4885MAPT 3387/4885 |
| US-20200331872-A1 | METHIONINE METABOLIC PATHWAY INHIBITORS | GSS, MTR, CTH | MEN1 1485/4885KMT2A 2664/4885MAPT 3387/4885 |
| US-20230250086-A1 | METHIONINE METABOLIC PATHWAY INHIBITORS | GSS, MTR, CTH | MEN1 1485/4885KMT2A 2664/4885MAPT 3387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.