Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.52 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.46 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 5/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17298073 | 0.77 | PARP1 (0.65) | TNKS2ACVR1DDAH1ADORA3PARP1 | |
| SCHEMBL28279923 | 0.77 | TNKS2 (0.58) | TNKS2ACVR1DDAH1ADORA3PARP1 | |
| SCHEMBL13892327 | 0.76 | TNKS2 (0.57) | TNKS2ACVR1DDAH1ADORA3PARP1 | |
| SCHEMBL61188 | 0.73 | TNKS2 (0.50) | TNKS2ACVR1DDAH1ADORA3L3MBTL1 | |
| SCHEMBL3826724 | 0.69 | TNKS2 (1.00) | TNKS2DDAH1PARP1ALDH1A1NPC1 | |
| SCHEMBL30176850 | 0.69 | TNKS2 (1.00) | TNKS2DDAH1PARP1ALDH1A1NPC1 | |
| SCHEMBL21185368 | 0.68 | PIK3CD (0.47) | L3MBTL1ALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL21185379 | 0.67 | CRHBP (0.42) | ALDH1A1GAAMAPTSMN1; SMN2KMT2A | |
| SCHEMBL21127220 | 0.65 | PARP1 (0.64) | TNKS2ACVR1PARP1PARP14NPC1 | |
| SCHEMBL19992162 | 0.65 | PARP1 (0.64) | TNKS2ACVR1PARP1ALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019143874-A1 | SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2019-07-25 | — | — | WO | disclosed |