Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 6/20 | 0.76 |
| ▸ | PLA2G5 | P39877 | 3/20 | 0.76 |
| ▸ | FAAH | O00519 | 5/20 | 0.49 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CES2 | O00748 | 4/20 | 0.42 |
| ▸ | CES1 | P23141 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | CPA1 | P15085 | 1/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2118667 | 1.00 | PLA2G2A (0.76) | PLA2G2APLA2G5FAAHPLA2G4ASMN1; SMN2 | |
| SCHEMBL30798618 | 0.86 | PLA2G2A (1.00) | PLA2G2APLA2G5FAAHPLA2G4ASMN1; SMN2 | |
| SCHEMBL29948915 | 0.86 | PLA2G2A (1.00) | PLA2G2APLA2G5FAAHPLA2G4ASMN1; SMN2 | |
| SCHEMBL30018617 | 0.85 | FAAH (0.62) | PLA2G2APLA2G5FAAHSMN1; SMN2MEN1 | |
| SCHEMBL30018188 | 0.85 | FAAH (0.62) | PLA2G2APLA2G5FAAHSMN1; SMN2MEN1 | |
| SCHEMBL2119435 | 0.85 | PLA2G2A (0.70) | PLA2G2APLA2G5FAAHPLA2G4ASMN1; SMN2 | |
| SCHEMBL2119429 | 0.85 | PLA2G2A (0.70) | PLA2G2APLA2G5FAAHPLA2G4ASMN1; SMN2 | |
| SCHEMBL30076306 | 0.84 | FAAH (0.60) | PLA2G2APLA2G5FAAHSMN1; SMN2MEN1 | |
| SCHEMBL2120792 | 0.82 | PLA2G2A (0.69) | PLA2G2APLA2G5FAAHPLA2G4ASMN1; SMN2 | |
| SCHEMBL2120784 | 0.82 | PLA2G2A (0.69) | PLA2G2APLA2G5FAAHPLA2G4ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8580852-B2 | 2-oxamide inhibitors of phospholipase A2 activity and cellular arachidonate release based on dipeptides and pseudopeptides | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-11-12 | — | — | US | disclosed |
| US-20120095096-A1 | 2-OXAMIDE INHIBITORS OF PHOSPHOLIPASE A2 ACTIVITY AND CELLULAR ARACHIDONATE RELEASE BASED ON DIPEPTIDES AND PSEUDOPEPTIDES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-04-19 | — | — | US | disclosed |
| WO-2010123832-A2 | 2-OXAMIDE INHIBITORS OF PHOSPHOLIPASE A2 ACTIVITY AND CELLULAR ARACHIDONATE RELEASE BASED ON DIPEPTIDES AND PSEUDOPEPTIDES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095096-A1 | 2-OXAMIDE INHIBITORS OF PHOSPHOLIPASE A2 ACTIVITY AND CELLULAR ARACHIDONATE RELEASE BASED ON DIPEPTIDES AND PSEUDOPEPTIDES | PLA2G2E, PLA2G4A, PLAA | PLA2G2A 6/4885PLA2G5 16/4885FAAH 575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.