Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.39 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14458708 | 1.00 | KDM4E (0.52) | KDM4EHTR1AALDH1A1MAPTGAA | |
| SCHEMBL9684093 | 0.83 | SMN1; SMN2 (0.49) | KDM4EALDH1A1MAPTGAASMN1; SMN2 | |
| SCHEMBL9684084 | 0.83 | SMN1; SMN2 (0.49) | KDM4EALDH1A1MAPTGAASMN1; SMN2 | |
| SCHEMBL19744209 | 0.81 | ATM (0.43) | ALDH1A1MAPTGAASMN1; SMN2HTT | |
| SCHEMBL19744095 | 0.81 | ATM (0.43) | ALDH1A1MAPTGAASMN1; SMN2HTT | |
| SCHEMBL9562317 | 0.81 | MEN1 (0.45) | ALDH1A1RAD51KMT2AMEN1 | |
| SCHEMBL14459499 | 0.80 | EPHX2 (0.46) | KDM4EALDH1A1MAPTGAASMN1; SMN2 | |
| SCHEMBL27384157 | 0.79 | ZDHHC2 (0.40) | KDM4EALDH1A1MAPTGAASMN1; SMN2 | |
| SCHEMBL18397749 | 0.79 | LY96 (0.38) | KDM4EALDH1A1MAPTHTTTSHR | |
| SCHEMBL18397751 | 0.79 | LY96 (0.38) | KDM4EALDH1A1MAPTHTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240109905-A1 | 4-ALKOXY-6-OXO-PYRIDAZINE DERIVATIVES MODULATING NLRP3 | JANSSEN PHARMACEUTICA NV (BE) | 2024-04-04 | — | — | US | disclosed |
| EP-4301753-A1 | 4-ALKOXY-6-OXO-PYRIDAZINE DERIVATIVES MODULATING NLRP3 | Janssen Pharmaceutica NV (BE) | 2024-01-10 | — | — | EP | disclosed |
| CN-117083272-A | 4-alkoxy-6-oxo-pyridazine derivatives that modulate NLRP3 | 詹森药业有限公司 | 2023-11-17 | — | — | CN | disclosed |
| WO-2022184842-A1 | 4-ALKOXY-6-OXO-PYRIDAZINE DERIVATIVES MODULATING NLRP3 | JANSSEN PHARMACEUTICA NV (BE) | 2022-09-09 | — | — | WO | disclosed |
| US-20210101877-A1 | ANTI-INFECTIVE AGENTS | UNIVERSITY OF DUNDEE (GB) | 2021-04-08 | — | — | US | disclosed |
| US-20190225592-A1 | ANTI-INFECTIVE AGENTS | UNIVERSITY OF DUNDEE (GB) | 2019-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240109905-A1 | 4-ALKOXY-6-OXO-PYRIDAZINE DERIVATIVES MODULATING NLRP3 | NLRP3, NLRP1, PYCARD | KDM4E 2109/4885HTR1A 1464/4885ALDH1A1 1823/4885 |
| US-20210101877-A1 | ANTI-INFECTIVE AGENTS | C1R, RRS1, ARG1 | KDM4E 2159/4885HTR1A 2405/4885ALDH1A1 3749/4885 |
| US-20190225592-A1 | ANTI-INFECTIVE AGENTS | C1R, ARG1, MSR1 | KDM4E 2344/4885HTR1A 2561/4885ALDH1A1 3685/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.