Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 2/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9684093 | 1.00 | SMN1; SMN2 (0.49) | SMN1; SMN2KDM4EALDH1A1CYP1A2HPGD | |
| SCHEMBL14459499 | 0.84 | EPHX2 (0.46) | SMN1; SMN2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL14458708 | 0.83 | KDM4E (0.52) | SMN1; SMN2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL21187006 | 0.83 | KDM4E (0.52) | SMN1; SMN2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL19743723 | 0.79 | PDE4A (0.42) | SMN1; SMN2KDM4EALDH1A1CYP1A2HPGD | |
| SCHEMBL29986171 | 0.79 | LMNA (0.44) | SMN1; SMN2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL19744050 | 0.79 | LMNA (0.44) | SMN1; SMN2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL21187112 | 0.79 | LMNA (0.44) | SMN1; SMN2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL19744159 | 0.79 | PDE4A (0.42) | SMN1; SMN2KDM4EALDH1A1CYP1A2HPGD | |
| SCHEMBL4251629 | 0.78 | GAA (0.51) | SMN1; SMN2ALDH1A1KMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003810-B2 | Process for preparing Nebivolol | ZACH SYSTEM S.P.A. (IT) | 2011-08-23 | — | — | US | disclosed |
| US-8003810-B2 | Process for preparing Nebivolol | ZACH SYSTEM S.P.A. (IT) | 2011-08-23 | — | — | US | disclosed |
| US-20100076206-A1 | PROCESS FOR PREPARING NEBIVOLOL | ZACH SYSTEM S.P.A. (IT) | 2010-03-25 | — | — | US | disclosed |
| US-20100076206-A1 | PROCESS FOR PREPARING NEBIVOLOL | ZACH SYSTEM S.P.A. (IT) | 2010-03-25 | — | — | US | disclosed |
| US-5171865-A | Process for the preparation of optically active 4-oxo-1-benzopyran-2-carboxylic acid derivatives and intermediates thereof | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1992-12-15 | — | — | US | disclosed |
| EP-0331078-A2 | Process for the preparation of optically active 4-oxo-1-benzopyran-2-carboxylic acid derivatives and intermediates thereof | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1989-09-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100076206-A1 | PROCESS FOR PREPARING NEBIVOLOL | ADRB1, ADRB2, ADRA1B | SMN1; SMN2 3992/4885KDM4E 2048/4885ALDH1A1 281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.