Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.47 |
| ▸ | KIF11 | P52732 | 8/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.39 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.39 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2118385 | 0.91 | TRPV1 (0.45) | TRPV1KIF11CYP11B2CYP11B1 | |
| SCHEMBL2120061 | 0.81 | KIF11 (0.45) | TRPV1KIF11CYP11B2CYP11B1 | |
| SCHEMBL2119933 | 0.79 | TRPV1 (0.58) | TRPV1 | |
| SCHEMBL2118506 | 0.77 | TRPV1 (0.56) | TRPV1 | |
| SCHEMBL2118943 | 0.77 | TRPV1 (0.56) | TRPV1 | |
| SCHEMBL10068660 | 0.77 | TRPV1 (0.56) | TRPV1 | |
| SCHEMBL2118948 | 0.77 | TRPV1 (0.56) | TRPV1 | |
| SCHEMBL1686401 | 0.74 | TRPV1 (0.59) | TRPV1KIF11 | |
| SCHEMBL2118642 | 0.74 | TRPV1 (0.58) | TRPV1 | |
| SCHEMBL2117473 | 0.74 | ALDH1A1 (0.49) | TRPV1KIF11CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120095002-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | N.V. ORGANON (NL) | 2012-04-19 | — | — | US | disclosed |
| EP-2393788-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | N.V. Organon (NL) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010089297-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | N.V. ORGANON (NL) | 2010-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095002-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | TRPV1, TRPV5, P2RX5 | TRPV1 1/4885KIF11 3198/4885CYP11B2 1187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.