Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.36 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28471532 | 1.00 | ALDH1A1 (0.40) | ALDH1A1TSHRMAPK1CYP2C19HIF1A | |
| SCHEMBL30817826 | 1.00 | ALDH1A1 (0.40) | ALDH1A1TSHRMAPK1CYP2C19HIF1A | |
| SCHEMBL21187358 | 0.86 | IRAK4 (0.36) | ALDH1A1TSHRMAPK1CYP2C19HIF1A | |
| SCHEMBL30823285 | 0.85 | MEN1 (0.38) | ALDH1A1TSHRMAPK1CYP2C19HIF1A | |
| SCHEMBL21187331 | 0.85 | MEN1 (0.38) | ALDH1A1TSHRMAPK1CYP2C19HIF1A | |
| SCHEMBL21178069 | 0.85 | MEN1 (0.38) | ALDH1A1TSHRMAPK1CYP2C19HIF1A | |
| SCHEMBL30790695 | 0.82 | LRRK2 (0.36) | ALDH1A1TSHRMAPK1CYP2C19HIF1A | |
| SCHEMBL16039400 | 0.82 | LRRK2 (0.36) | ALDH1A1TSHRMAPK1CYP2C19HIF1A | |
| SCHEMBL16039402 | 0.82 | LRRK2 (0.36) | ALDH1A1TSHRMAPK1CYP2C19HIF1A | |
| SCHEMBL21187336 | 0.82 | DCLK1 (0.39) | ALDH1A1TSHRMAPK1CYP2C19HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200353101-A1 | DNA-PK INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED | 2020-11-12 | — | — | US | disclosed |
| WO-2019143678-A1 | DNA-PK INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2019-07-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200353101-A1 | DNA-PK INHIBITORS | POLK, DTYMK, DCK | ALDH1A1 3073/4885TSHR 4246/4885MAPK1 1217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.