Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.39 |
| ▸ | PDE4A | P27815 | 5/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.39 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.36 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | VEGFA | P15692 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25370111 | 0.88 | POLB (0.46) | PDE4BALDH1A1TSHRPOLBHPGD | |
| SCHEMBL2353542 | 0.85 | POLB (0.47) | PDE4BALDH1A1TSHRPOLBHPGD | |
| SCHEMBL28371304 | 0.82 | SYK (0.45) | SYKPDE4DPDE4BPDE4APDE4C | |
| SCHEMBL28375415 | 0.82 | ALDH1A3 (0.49) | SYKPDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7361245 | 0.81 | ALDH1A1 (0.58) | PDE4DPDE4BPDE4APDE4CALDH1A1 | |
| SCHEMBL28373126 | 0.81 | ALDH1A1 (0.58) | PDE4DPDE4BPDE4APDE4CALDH1A1 | |
| SCHEMBL21191007 | 0.77 | SYK (0.44) | SYKPDE4DPDE4BPDE4APDE4C | |
| SCHEMBL24252789 | 0.77 | SYK (0.44) | SYKPDE4DPDE4BPDE4APDE4C | |
| SCHEMBL275132 | 0.77 | PTGDR2 (0.44) | SYKPDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7355948 | 0.76 | SYK (0.39) | SYKPDE4DPDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3741758-A1 | BROMODOMAIN INHIBITOR COMPOUND AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2020-11-25 | — | — | EP | disclosed |
| WO-2019141131-A1 | BROMODOMAIN INHIBITOR COMPOUND AND USE THEREOF | 中国科学院上海药物研究所 | 2019-07-25 | — | — | WO | disclosed |
| US-9359548-B2 | Organic electroluminescent device | UDC IRELAND LIMITED (IE) | 2016-06-07 | — | — | US | disclosed |