Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.36 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10686101 | 0.83 | GRIN2D (0.40) | ALDH1A1TDP1POLBHTTHIF1A | |
| SCHEMBL3667566 | 0.79 | GRIN2D (0.43) | ALDH1A1TDP1POLBHTTHIF1A | |
| SCHEMBL29860351 | 0.79 | ALDH1A1 (0.43) | ALDH1A1TDP1POLBHIF1AALDH3A1 | |
| SCHEMBL1340438 | 0.79 | ALDH1A1 (0.43) | ALDH1A1TDP1POLBHIF1AALDH3A1 | |
| SCHEMBL387166 | 0.77 | POLB (0.40) | ALDH1A1TDP1POLBHTTHIF1A | |
| SCHEMBL214271 | 0.77 | ALDH1A1 (0.45) | ALDH1A1TDP1POLBHTTALDH3A1 | |
| SCHEMBL73931 | 0.74 | TDP1 (0.50) | ALDH1A1TDP1POLBHTTHIF1A | |
| SCHEMBL26666526 | 0.73 | MAPT (0.40) | ALDH1A1TDP1POLBHTTHIF1A | |
| SCHEMBL29860564 | 0.73 | MAPT (0.40) | ALDH1A1TDP1POLBHTTHIF1A | |
| SCHEMBL10944668 | 0.73 | TDP1 (0.54) | ALDH1A1TDP1POLBHTTGRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 140 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160264612-A1 | MASSIVE PARALLEL METHOD FOR DECODING DNA AND RNA | UNIV COLUMBIA (US) | 2016-09-15 | — | — | US | claimed |
| US-20130096015-A1 | Massive Parallel Method For Decoding DNA And RNA | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2013-04-18 | — | — | US | claimed |
| US-7345159-B2 | Massive parallel method for decoding DNA and RNA | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2008-03-18 | — | — | US | claimed |
| EP-1790736-A2 | Massive parallel method for decoding DNA and RNA | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2007-05-30 | — | — | EP | claimed |
| EP-1337541-B1 | Massive parallel method for decoding DNA and RNA | UNIV COLUMBIA (US) | 2007-03-07 | — | — | EP | claimed |
| US-20040185466-A1 | to detect single nucleotide polymorphisms, genetic mutation, gene expression, forensic identification, disease association, DNA/genomic sequencing and translation/transcription analysis; solid phase synthesis | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK. | 2004-09-23 | — | — | US | claimed |
| US-6664079-B2 | Sequencing nucleic acid; obtain nucleotide sequences, incubate in reaction mixture, apply to solid support, determine nucleotide sequences | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2003-12-16 | — | — | US | claimed |
| US-20020102586-A1 | Sequencing nucleic acid; obtain nucleotide sequences, incubate in reaction mixture, apply to solid support, determine nucleotide sequences | NATIONAL SCIENCE FOUNDATION | 2002-08-01 | — | — | US | claimed |
| US-11940413-B2 | Methods and devices for sequencing nucleic acids in smaller batches | IsoPlexis Corporation (US) | 2024-03-26 | — | — | US | disclosed |
| US-20240076731-A1 | METHODS AND COMPOSITIONS FOR INCORPORATING NUCLEOTIDES | QIAGEN SCIENCES, LLC | 2024-03-07 | — | — | US | disclosed |
| US-20240060128-A1 | METHODS AND COMPOSITIONS FOR INCORPORATING NUCLEOTIDES | QIAGEN WALTHAM, INC. | 2024-02-22 | — | — | US | disclosed |
| US-20230407384-A1 | METHODS AND COMPOSITIONS FOR INCORPORATING NUCLEOTIDES | QIAGEN WALTHAM, INC. | 2023-12-21 | — | — | US | disclosed |
| US-20210230686-A1 | METHODS AND COMPOSITIONS FOR INCORPORATING NUCLEOTIDES | IsoPlexis Corporation | 2021-07-29 | — | — | US | disclosed |
| US-20210231609-A1 | METHODS AND DEVICES FOR SEQUENCING NUCLEIC ACIDS IN SMALLER BATCHES | IsoPlexis Corporation | 2021-07-29 | — | — | US | disclosed |
| US-20040185466-A1 | to detect single nucleotide polymorphisms, genetic mutation, gene expression, forensic identification, disease association, DNA/genomic sequencing and translation/transcription analysis; solid phase synthesis | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK. | 2004-09-23 | — | — | US | disclosed |
| EP-1337541-A4 | MASSIVE PARALLEL METHOD FOR DECODING DNA AND RNA | UNIV COLUMBIA (US) | 2004-07-14 | — | — | EP | disclosed |
| US-6664079-B2 | Sequencing nucleic acid; obtain nucleotide sequences, incubate in reaction mixture, apply to solid support, determine nucleotide sequences | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2003-12-16 | — | — | US | disclosed |
| EP-1337541-A2 | Massive parallel method for decoding DNA and RNA | The Trustees of Columbia University in the City of New York (US) | 2003-08-27 | — | — | EP | disclosed |
| US-20020102586-A1 | Sequencing nucleic acid; obtain nucleotide sequences, incubate in reaction mixture, apply to solid support, determine nucleotide sequences | NATIONAL SCIENCE FOUNDATION | 2002-08-01 | — | — | US | disclosed |
| WO-2002029003-A2 | MASSIVE PARALLEL METHOD FOR DECODING DNA AND RNA | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2002-04-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210230686-A1 | METHODS AND COMPOSITIONS FOR INCORPORATING NUCLEOTIDES | NT5C2, NOP2, NT5C3B | ALDH1A1 4837/4885TDP1 116/4885POLB 44/4885 |
| US-20160264612-A1 | MASSIVE PARALLEL METHOD FOR DECODING DNA AND RNA | RNGTT, NSUN2, RNMT | ALDH1A1 3815/4885TDP1 299/4885POLB 25/4885 |
| US-20240076731-A1 | METHODS AND COMPOSITIONS FOR INCORPORATING NUCLEOTIDES | NT5C2, NOP2, NT5C3B | ALDH1A1 4837/4885TDP1 116/4885POLB 44/4885 |
| US-20230407384-A1 | METHODS AND COMPOSITIONS FOR INCORPORATING NUCLEOTIDES | NT5C2, NOP2, NT5C3B | ALDH1A1 4837/4885TDP1 116/4885POLB 44/4885 |
| US-20240060128-A1 | METHODS AND COMPOSITIONS FOR INCORPORATING NUCLEOTIDES | NT5C2, NOP2, NT5C3B | ALDH1A1 4837/4885TDP1 116/4885POLB 44/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.