Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 8/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29866952 | 0.83 | HCRTR1 (0.46) | ALDH1A1CYP2C19BACE1 | |
| SCHEMBL21200277 | 0.80 | ALDH1A1 (0.43) | ALDH1A1MEN1HTTKMT2ACYP1A2 | |
| SCHEMBL21201116 | 0.72 | CBLB (0.44) | POLBMAPT | |
| SCHEMBL21200967 | 0.71 | MEN1 (0.35) | MEN1HTTKMT2ACYP1A2POLB | |
| SCHEMBL21200585 | 0.68 | ALDH1A1 (0.51) | ALDH1A1MEN1HTTKMT2ACYP2C9 | |
| SCHEMBL11858223 | 0.67 | GPR35 (0.67) | MEN1KMT2APOLBMAPT | |
| SCHEMBL21200853 | 0.67 | HCRTR1 (0.45) | ALDH1A1HTTCYP1A2POLBCYP2C9 | |
| SCHEMBL28148358 | 0.67 | KMT2A (0.42) | MEN1HTTKMT2ACYP1A2POLB | |
| SCHEMBL24028223 | 0.67 | KMT2A (0.48) | ALDH1A1MEN1KMT2ACYP1A2POLB | |
| SCHEMBL16798502 | 0.66 | THRB (0.43) | ALDH1A1MEN1KMT2APOLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3743063-A1 | INHIBITORS OF CBL-B AND METHODS OF USE THEREOF | Nurix Therapeutics, Inc. (US) | 2020-12-02 | — | — | EP | disclosed |
| WO-2019148005-A1 | INHIBITORS OF CBL-B AND METHODS OF USE THEREOF | NURIX THERAPEUTICS, INC. (US) | 2019-08-01 | — | — | WO | disclosed |