Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 10/20 | 0.46 |
| ▸ | MGAM | O43451 | 9/20 | 0.46 |
| ▸ | AMY1A | P0DUB6 | 9/20 | 0.46 |
| ▸ | SI | P14410 | 9/20 | 0.46 |
| ▸ | MGAM2 | Q2M2H8 | 9/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | F2 | P00734 | 2/20 | 0.46 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | F12 | P00748 | 6/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23591735 | 0.77 | DGAT1 (0.46) | DGAT1GAAMGAMAMY1ASI | |
| SCHEMBL18675329 | 0.76 | DGAT1 (0.61) | DGAT1GAAMGAMAMY1ASI | |
| SCHEMBL3689328 | 0.76 | GAA (0.58) | DGAT1GAAMGAMAMY1ASI | |
| SCHEMBL22641209 | 0.74 | DGAT1 (0.43) | DGAT1GAAMGAMAMY1ASI | |
| SCHEMBL15426053 | 0.72 | DGAT1 (0.66) | DGAT1GAAMGAMAMY1ASI | |
| SCHEMBL20850940 | 0.71 | DGAT1 (0.50) | DGAT1GAAMGAMAMY1ASI | |
| SCHEMBL25494140 | 0.71 | MAPT (0.44) | DGAT1GAAMGAMAMY1ASI | |
| SCHEMBL23110047 | 0.70 | DGAT1 (0.49) | DGAT1GAAMGAMAMY1ASI | |
| SCHEMBL14362020 | 0.69 | DGAT1 (0.61) | DGAT1GAAMGAMAMY1ASI | |
| SCHEMBL21736909 | 0.69 | DGAT1 (0.51) | DGAT1GAAMGAMAMY1ASI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3119768-B1 | 3,4-BROMO OR -SULFONATE SUBSTITUTED 1H-PYRROLE-2,5-DIONE DERIVATIVES AS TYPE III DEIODINASE (DIO3) INHIBITORS FOR TREATING DEPRESSIONS AND CANCER | HADASIT MED RES SERVICE (IL) | 2019-07-31 | — | — | EP | disclosed |