Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | CA12 | O43570 | 2/20 | 1.00 |
| ▸ | CA1 | P00915 | 2/20 | 1.00 |
| ▸ | CA2 | P00918 | 2/20 | 1.00 |
| ▸ | CA7 | P43166 | 2/20 | 1.00 |
| ▸ | CA9 | Q16790 | 2/20 | 1.00 |
| ▸ | APAF1 | O14727 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 4/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.33 |
| ▸ | TSSK1B | Q9BXA7 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Calanolide C SCHEMBL7036135 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CA12CA1CA2CA7 | |
| Costatolide SCHEMBL30544160 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CA12CA1CA2CA7 | |
| (-)-Calanolide A SCHEMBL29803798 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CA12CA1CA2CA7 | |
| Calanolide A SCHEMBL140017 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CA12CA1CA2CA7 | |
| Calanolide A SCHEMBL30075237 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CA12CA1CA2CA7 | |
| (-)-Calanolide A SCHEMBL8927754 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CA12CA1CA2CA7 | |
| Costatolide SCHEMBL29397227 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CA12CA1CA2CA7 | |
| Costatolide SCHEMBL29402951 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CA12CA1CA2CA7 | |
| Costatolide SCHEMBL8927756 | 1.00 | ALDH1A1 (1.00) | ALDH1A1CA12CA1CA2CA7 | |
| SCHEMBL19596735 | 0.90 | ALDH1A1 (0.82) | ALDH1A1CA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 586 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210008104-A1 | COMPOSITIONS AND METHODS FOR INHIBITING HIV-1 REVERSE TRANSCRIPTASE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2021-01-14 | — | — | US | claimed |
| EP-3664811-A2 | COMPOSITIONS AND METHODS FOR INHIBITING HIV-1 REVERSE TRANSCRIPTASE | The U.S.A. as represented by the Secretary, Department of Health and Human Services (US) | 2020-06-17 | — | — | EP | claimed |
| CN-111163783-A | Compositions and methods for inhibiting HIV-1 reverse transcriptase | 美国政府卫生与公众服务部 | 2020-05-15 | — | — | CN | claimed |
| WO-2019032749-A2 | COMPOSITIONS AND METHODS FOR INHIBITING HIV-1 REVERSE TRANSCRIPTASE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES (US) | 2019-02-14 | — | — | WO | claimed |
| US-9487476-B2 | Catechol diethers as potent anti-HIV agents | YALE UNIVERSITY (US) | 2016-11-08 | — | — | US | claimed |
| EP-2720754-B1 | LEUKOTOXIN E/D AS A NEW ANTI-INFLAMMATORY AGENT AND MICROBICIDE | UNIV NEW YORK (US) | 2016-10-19 | — | — | EP | claimed |
| EP-2970369-A2 | CHOLESTOSOME VESICLES FOR INCORPORATION OF MOLECULES INTO CHYLOMICRONS | Schentag, Jerome, J. (US) | 2016-01-20 | — | — | EP | claimed |
| US-20150105351-A1 | COMPOUNDS AND METHODS FOR TREATING HIV INFECTIONS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-04-16 | — | — | US | claimed |
| CN-102753526-B | Pyridinone hydroxycyclopentyl carboxamides: HIV integrase inhibitors with therapeutic applications | UNIV GEORGIA | 2014-11-26 | — | — | CN | claimed |
| US-20140288017-A1 | CATECHOL DIETHERS AS POTENT ANTI-HIV AGENTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-09-25 | — | — | US | claimed |
| US-20020086898-A1 | Calanolide and related antiviral compounds, compositions, and uses thereof | BOYD MICHAEL R (US) | 2002-07-04 | — | — | US | claimed |
| EP-0633887-B1 | CALANOLIDE ANTIVIRAL COMPOUNDS, COMPOSITIONS AND USES THEREOF | US HEALTH (US) | 1999-05-19 | — | — | EP | claimed |
| EP-0699202-B1 | CALANOLIDE AND RELATED ANTIVIRAL COMPOUNDS, COMPOSITIONS, AND USES THEREOF | US HEALTH (US) | 1999-02-03 | — | — | EP | claimed |
| US-5859049-A | ANTIHEPATITIS B COMPRISING CALANOLIDE A AND B, DIHYDROCALANOLIDE A AND B, COSTATOLIDE, DIHYDROCOSTATOLIDE, SOULATTROLIDE, AND DIHYDROSOULATTROLIDE. | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1999-01-12 | — | — | US | claimed |
| US-5608085-A | Synthesis of optically active calanolides A and B and enantiomers and related compounds | THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION (US) | 1997-03-04 | — | — | US | claimed |
| US-5591770-A | TREATING HUMAN T-CELL LYMPHOMA/LEUKEMIA INFECTIONS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1997-01-07 | — | — | US | claimed |
| WO-1996026934-A1 | SYNTHESIS OF OPTICALLY ACTIVE CALANOLIDES A AND B AND ENANTIOMERS AND RELATED COMPOUNDS | THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION (US) | 1996-09-06 | — | — | WO | claimed |
| EP-0699202-A1 | CALANOLIDE AND RELATED ANTIVIRAL COMPOUNDS, COMPOSITIONS, AND USES THEREOF | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1996-03-06 | — | — | EP | claimed |
| EP-0633887-A1 | CALANOLIDE ANTIVIRAL COMPOUNDS, COMPOSITIONS AND USES THEREOF | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1995-01-18 | — | — | EP | claimed |
| WO-1994028000-A1 | CALANOLIDE AND RELATED ANTIVIRAL COMPOUNDS, COMPOSITIONS, AND USES THEREOF | THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1994-12-08 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140288017-A1 | CATECHOL DIETHERS AS POTENT ANTI-HIV AGENTS | COMT, NNMT, PNMT | ALDH1A1 572/4885CA12 4365/4885CA1 4826/4885 |
| US-20020086898-A1 | Calanolide and related antiviral compounds, compositions, and uses thereof | ZC3HAV1, RPL35, ZC3HAV1L | ALDH1A1 4177/4885CA12 3103/4885CA1 4282/4885 |
| US-20150105351-A1 | COMPOUNDS AND METHODS FOR TREATING HIV INFECTIONS | POLM, POLRMT, DHFR | ALDH1A1 1200/4885CA12 3973/4885CA1 4637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.