Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.72 |
| ▸ | NPC1 | O15118 | 7/20 | 0.72 |
| ▸ | RAB9A | P51151 | 6/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.72 |
| ▸ | LMNA | P02545 | 3/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.72 |
| ▸ | MEN1 | O00255 | 12/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 12/20 | 0.71 |
| ▸ | POLB | P06746 | 3/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1086712 | 1.00 | MAPT (0.72) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2120386 | 1.00 | MAPT (0.72) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3833049 | 0.99 | MAPT (0.73) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3833053 | 0.99 | MAPT (0.73) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3833055 | 0.99 | MAPT (0.73) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16645429 | 0.85 | MAPT (0.81) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL305974 | 0.84 | MAPT (1.00) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL305975 | 0.84 | MAPT (1.00) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15765846 | 0.81 | MAPT (0.73) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1689490 | 0.74 | MAPT (0.70) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0971682-B2 | DYEING COMPOSITION FOR KERATIN FIBRES AND DYEING METHOD USING SAME | OREAL (FR) | 2009-09-23 | — | — | EP | claimed |
| US-7517367-B2 | Cationic naphthyldiazo dyes and keratin fibers-coloring agents containing these dyes | WELLA AG (DE) | 2009-04-14 | — | — | US | claimed |
| US-20080167453-A1 | Cationic Naphthyldiazo Dyes and Keratin Fibers-Coloring Agents Containing These Dyes | WELLA AG (DE) | 2008-07-10 | — | — | US | claimed |
| EP-1740657-B1 | CATIONIC NAPHTHYLDIAZO DYES AND AGENTS CONTAINING SAID DYES USED TO COLOUR KERATIN FIBRES | WELLA AG (DE) | 2007-09-12 | — | — | EP | claimed |
| EP-1424988-B1 | LIGHTENING DYE WITH DIRECT-DYEING COLORANTS | WELLA AG (DE) | 2005-11-09 | — | — | EP | claimed |
| EP-0971682-B1 | DYEING COMPOSITION FOR KERATIN FIBRES AND DYEING METHOD USING SAME | OREAL (FR) | 2004-03-17 | — | — | EP | claimed |
| EP-0895472-B1 | METHOD FOR DYEING KERATIN FIBRES WITH OXIDATION DYE PRECURSORS AND DIRECT POWDER DYES | OREAL (FR) | 2004-03-10 | — | — | EP | claimed |
| US-20040034945-A1 | Lightening dye with direct-dyeing colorants | WELLA AKTIENGESELLSCHAFT (DE) | 2004-02-26 | — | — | US | claimed |
| EP-0969798-B1 | OXIDATION DYEING COMPOSITION FOR KERATIN FIBRES AND DYEING METHOD USING SAID COMPOSITION | OREAL (FR) | 2003-07-23 | — | — | EP | claimed |
| EP-1047376-B1 | KERATINOUS FIBRE DYEING COMPOSITION CONTAINING A LACCASE AND DYEING METHOD USING SAME | OREAL (FR) | 2001-05-23 | — | — | EP | claimed |
| US-20140299149-A1 | COMPOSITIONS AND METHODS FOR TREATING KERATIN BASED FIBERS | COOLWAY INC (US) | 2014-10-09 | — | — | US | disclosed |
| US-20140261517-A1 | COMPOSITIONS AND METHODS FOR TREATING KERATIN BASED FIBERS | COOLWAY INC. (US) | 2014-09-18 | — | — | US | disclosed |
| US-8771658-B2 | Compositions and methods for treating keratin based fibers | COOLWAY INC. (US) | 2014-07-08 | — | — | US | disclosed |
| US-20120093755-A1 | COMPOSITIONS AND METHODS FOR TREATING KERATIN BASED FIBERS | MANEWORX INC. (US) | 2012-04-19 | — | — | US | disclosed |
| EP-1825883-B1 | Agents for coloring keratin fibers | PROCTER & GAMBLE (US) | 2010-04-14 | — | — | EP | disclosed |
| US-6190421-B1 | OXIDATION DYE PRECURSOR; OPTIONALLY A COUPLER; DIRECT POWDER CATIONIC DYE | L'OREAL (FR) | 2001-02-20 | — | — | US | disclosed |
| WO-2001000144-A2 | HAIR COMPOSITION COMPRISING AN OXIDASE AND CYCLODEXTRIN | LION CORPORATION (JP) | 2001-01-04 | — | — | WO | disclosed |
| WO-2000078273-A2 | PROCESS FOR PRODUCING A HAIRDYE COMPOSITION | LION CORPORATION (JP) | 2000-12-28 | — | — | WO | disclosed |
| WO-2000059459-A1 | HAIRDYE COMPOSITION OF SINGLE PREPARATION TYPE CONTAINING AN OXIDASE | LION CORPORATION (JP) | 2000-10-12 | — | — | WO | disclosed |
| US-6045591-A | BLEACHING THE KERATIN FIBRES; AND APPLYING AT LEAST ONE PARTIALLY DISSOLVED BASIC DIRECT DYE AND AN AQUEOUS MEDIUM, WHERE THE DYE IS READY TO USE OR RESULTS FROM MIXING A PULVERULENT BASIC DIRECT DYE COMPOSITION AND AQUEOUS MEDIUM | L'OREAL (FR) | 2000-04-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167453-A1 | Cationic Naphthyldiazo Dyes and Keratin Fibers-Coloring Agents Containing These Dyes | KRT18, KPNB1, KPNA3 | MAPT 1600/4885ALDH1A1 1280/4885NPC1 1787/4885 |
| US-20040034945-A1 | Lightening dye with direct-dyeing colorants | KRT18, TUBB1, TUBA1C | MAPT 372/4885ALDH1A1 37/4885NPC1 4500/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.