Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 2/20 | 0.49 |
| ▸ | CTSK | P43235 | 2/20 | 0.49 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1716112 | 0.86 | CYP2C19 (0.53) | CTSSCTSKKCNQ2LMNAALDH1A1 | |
| SCHEMBL8350075 | 0.85 | CTSK (0.65) | CTSSCTSKCTSL | |
| SCHEMBL15828118 | 0.85 | CTSS (0.47) | CTSSCTSKKCNQ2LMNAALDH1A1 | |
| SCHEMBL9577303 | 0.82 | CTSS (0.48) | CTSSCTSKKCNQ2LMNAALDH1A1 | |
| SCHEMBL27774147 | 0.82 | LMNA (0.50) | CTSSCTSKKCNQ2LMNAALDH1A1 | |
| SCHEMBL13619700 | 0.82 | POLB (0.51) | LMNAALDH1A1CYP2C19EPHX1HSD17B10 | |
| SCHEMBL3036448 | 0.82 | EPHX1 (0.59) | CTSSCTSKKCNQ2LMNAALDH1A1 | |
| SCHEMBL1801672 | 0.81 | LMNA (0.56) | CTSSCTSKKCNQ2LMNAALDH1A1 | |
| SCHEMBL11508430 | 0.79 | KMT2A (0.56) | CTSSCTSKKCNQ2LMNAALDH1A1 | |
| SCHEMBL13020177 | 0.79 | LMNA (0.58) | KCNQ2LMNAALDH1A1HSD17B10CRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0983507-A1 | TRICYCLIC TETRAHYDROQUINOLINE DERIVATIVES AND TRICYCLIC TETRAHYDROQUINOLINE COMBINATORIAL LIBRARIES | Trega Biosciences, Inc. (US) | 2000-03-08 | — | — | EP | claimed |
| WO-1998034111-A1 | TRICYCLIC TETRAHYDROQUINOLINE DERIVATIVES AND TRICYCLIC TETRAHYDROQUINOLINE COMBINATORIAL LIBRARIES | TREGA BIOSCIENCES, INC. (US) | 1998-08-06 | — | — | WO | claimed |
| US-20140178606-A1 | CELLULOSE ACYLATE FILM, POLARIZER, AND LIQUID CRYSTAL DISPLAY DEVICE | FUJIFILM CORPORATION (JP) | 2014-06-26 | — | — | US | disclosed |
| US-8477275-B2 | Optical film and liquid crystal display device | FUJIFILM CORPORATION (JP) | 2013-07-02 | — | — | US | disclosed |
| US-20130128359-A1 | OPTICAL FILM, POLARIZING PLATE, AND LIQUID CRYSTAL DISPLAY APPARATUS | FUJIFILM CORPORATION (JP) | 2013-05-23 | — | — | US | disclosed |
| US-8420187-B2 | Cellulose acylate composition, cellulose acylate film, and its applications | FUJIFILM CORPORATION (JP) | 2013-04-16 | — | — | US | disclosed |
| WO-2013032016-A1 | CELLULOSE ACYLATE FILM, POLARIZER, AND LIQUID CRYSTAL DISPLAY DEVICE | FUJIFILM CORPORATION (JP) | 2013-03-07 | — | — | WO | disclosed |
| US-20120092594-A1 | OPTICAL FILM AND LIQUID CRYSTAL DISPLAY DEVICE | FUJIFILM CORPORATION (JP) | 2012-04-19 | — | — | US | disclosed |
| US-20120092595-A1 | Optical film, polarizing plate and liquid crystal display device | FUJIFILM CORPORATION (JP) | 2012-04-19 | — | — | US | disclosed |
| EP-1496838-B1 | SUBSTITUTED AMIDES | MERCK SHARP & DOHME (US) | 2010-11-03 | — | — | EP | disclosed |
| US-7816534-B2 | Substituted amides | MERCK SHARP & DOHME CORP. (US) | 2010-10-19 | — | — | US | disclosed |
| WO-2003086288-A2 | BICYCLIC AMIDES | MERCK & CO., INC. (US) | 2003-10-23 | — | — | WO | disclosed |
| WO-2003082190-A2 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2003-10-09 | — | — | WO | disclosed |
| WO-2003077847-A2 | SUBSTITUTED AMIDES | MERCK & CO., INC. (US) | 2003-09-25 | — | — | WO | disclosed |
| US-6274556-B1 | ADMINISTERING POLYPEPTIDE DERIVATIVE TO TREAT INFLAMMATORY BOWEL DISEASE AND TO PREVENT LEUKOCYTE INFILTRATION INTO TISSUES | MILLENNIUM PHARMACEUTICALS, INC. | 2001-08-14 | — | — | US | disclosed |
| EP-0983507-A1 | TRICYCLIC TETRAHYDROQUINOLINE DERIVATIVES AND TRICYCLIC TETRAHYDROQUINOLINE COMBINATORIAL LIBRARIES | Trega Biosciences, Inc. (US) | 2000-03-08 | — | — | EP | disclosed |
| US-5925527-A | SCREENING NEW PHARMACEUTICALS | TREGA BIOSCIENCES, INC. (US) | 1999-07-20 | — | — | US | disclosed |
| EP-0871670-A2 | INHIBITORS OF MAdCAM-1-MEDIATED INTERACTIONS AND METHODS OF USE THEREFOR | Leukosite, Inc. (US) | 1998-10-21 | — | — | EP | disclosed |
| WO-1998034111-A1 | TRICYCLIC TETRAHYDROQUINOLINE DERIVATIVES AND TRICYCLIC TETRAHYDROQUINOLINE COMBINATORIAL LIBRARIES | TREGA BIOSCIENCES, INC. (US) | 1998-08-06 | — | — | WO | disclosed |
| WO-1997025351-A2 | INHIBITORS OF MAdCAM-1-MEDIATED INTERACTIONS AND METHODS OF USE THEREFOR | LEUKOSITE, INC. (US) | 1997-07-17 | — | — | WO | disclosed |