Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 5/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.43 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19839025 | 0.88 | OPRL1 (0.49) | OPRL1OPRM1OPRD1OPRK1SLC6A9 | |
| SCHEMBL21228423 | 0.76 | — | — | |
| SCHEMBL19839005 | 0.74 | ALDH1A1 (0.47) | KMT2AALDH1A1CYP2C9CYP2C19SIGMAR1 | |
| SCHEMBL21228417 | 0.72 | HSD11B1 (0.31) | — | |
| SCHEMBL19839200 | 0.70 | SIGMAR1 (0.45) | OPRL1OPRM1OPRD1OPRK1SLC6A9 | |
| SCHEMBL25764397 | 0.70 | SLC6A9 (0.47) | OPRL1OPRM1OPRD1OPRK1SLC6A9 | |
| SCHEMBL19851191 | 0.70 | SIGMAR1 (0.45) | OPRL1OPRM1OPRD1OPRK1SLC6A9 | |
| SCHEMBL21228082 | 0.70 | OPRM1 (0.39) | OPRL1OPRM1KMT2ADDB1CRBN | |
| SCHEMBL19838995 | 0.69 | OPRL1 (0.41) | OPRL1OPRM1OPRD1OPRK1SLC6A9 | |
| SCHEMBL21228079 | 0.69 | KMT2A (0.42) | OPRL1OPRM1KMT2ADDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019152681-A1 | SPIRO-LACTAM AND BIS-SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | APTINYX INC. (US) | 2019-08-08 | — | — | WO | disclosed |