Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | HPN | P05981 | 1/20 | 0.37 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.36 |
| ▸ | GLRB | P48167 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31196986 | 0.87 | CA2 (0.43) | CA2CA1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL224048 | 0.80 | CA2 (0.64) | CA2CA1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL11330818 | 0.79 | SMN1; SMN2 (0.63) | CA2CA1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL13268589 | 0.78 | GABRA1 (0.48) | CA2CA1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL30341711 | 0.76 | MAPT (0.48) | CA2CA1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL21241383 | 0.76 | MAPT (0.48) | CA2CA1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL17309883 | 0.74 | CA2 (0.50) | CA2CA1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL891539 | 0.72 | CYP2C9 (0.63) | CA2CA1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL31196962 | 0.72 | CYP2C9 (0.63) | CA2CA1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL21241387 | 0.70 | MAPT (0.42) | CA2CA1SMN1; SMN2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11649220-B2 | Probucol derivative, preparation method therefor and use thereof | DEMOTECH.INC. (CN) | 2023-05-16 | — | — | US | disclosed |
| US-11649220-B2 | Probucol derivative, preparation method therefor and use thereof | DEMOTECH.INC. (CN) | 2023-05-16 | — | — | US | disclosed |
| US-11649220-B2 | Probucol derivative, preparation method therefor and use thereof | DEMOTECH.INC. (CN) | 2023-05-16 | — | — | US | disclosed |
| US-20210040052-A1 | PROBUCOL DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | DEMOTECH.INC. (CN) | 2021-02-11 | — | — | US | disclosed |
| US-20210040052-A1 | PROBUCOL DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | DEMOTECH.INC. (CN) | 2021-02-11 | — | — | US | disclosed |
| EP-3747863-A1 | PROBUCOL DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | DEMOTECH.INC. (CN) | 2020-12-09 | — | — | EP | disclosed |
| EP-3747863-A1 | PROBUCOL DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | DEMOTECH.INC. (CN) | 2020-12-09 | — | — | EP | disclosed |
| CN-108299263-B | Probucol derivative and preparation method and application thereof | 北京德默高科医药技术有限公司 | 2020-12-01 | — | — | CN | disclosed |
| WO-2019149091-A1 | PROBUCOL DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | 北京德默高科医药技术有限公司 | 2019-08-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210040052-A1 | PROBUCOL DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | PNLIP, FAR1, CETP | CA2 4494/4885CA1 4508/4885SMN1; SMN2 3302/4885 |
| US-11649220-B2 | Probucol derivative, preparation method therefor and use thereof | PNLIP, FAR1, CETP | CA2 4494/4885CA1 4508/4885SMN1; SMN2 3302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.