Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16026445 | 0.76 | KMT2A (0.51) | ALDH1A1L3MBTL1RXFP1KMT2AMEN1 | |
| SCHEMBL29944048 | 0.76 | ALDH1A1 (0.74) | ALDH1A1LMNAL3MBTL1RXFP1KMT2A | |
| SCHEMBL26938103 | 0.74 | ALDH1A1 (0.54) | ALDH1A1GAALMNAL3MBTL1HTT | |
| SCHEMBL31246118 | 0.72 | HTR1A (0.43) | ALDH1A1GAAKMT2AMEN1TSHR | |
| SCHEMBL23851238 | 0.72 | HTR1A (0.43) | ALDH1A1GAAKMT2AMEN1TSHR | |
| SCHEMBL2125884 | 0.72 | HPGD (0.74) | GAALMNARXFP1KMT2AMEN1 | |
| SCHEMBL3529190 | 0.72 | RXFP1 (0.55) | ALDH1A1L3MBTL1RXFP1KMT2ASMN1; SMN2 | |
| SCHEMBL12833234 | 0.72 | RXFP1 (0.63) | ALDH1A1GAALMNAL3MBTL1RXFP1 | |
| SCHEMBL29944077 | 0.71 | KMT2A (0.53) | ALDH1A1GAALMNAL3MBTL1HTT | |
| SCHEMBL31596392 | 0.70 | CFTR (0.44) | ALDH1A1L3MBTL1TSHRKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2443122-A1 | DIAZAHOMOADAMANTANE DERIVATIVES AND METHODS OF USE THEREOF | Abbott Laboratories (US) | 2012-04-25 | — | — | EP | disclosed |
| WO-2010145208-A1 | DIAZAHOMOADAMANTANE DERIVATIVES AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-12-23 | — | — | WO | disclosed |