Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.54 |
| ▸ | CA9 | Q16790 | 2/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA4 | P22748 | 1/20 | 0.54 |
| ▸ | CA7 | P43166 | 1/20 | 0.54 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.54 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL4072827 | 0.98 | CA12 (0.52) | CA12CA9CA1CA2CA4 | |
| SCHEMBL27661855 | 0.96 | CA12 (0.54) | CA12CA9CA1CA2CA4 | |
| Zinc Ion SCHEMBL2488069 | 0.96 | CA12 (0.54) | CA12CA9CA1CA2CA4 | |
| SCHEMBL10884908 | 0.96 | CA12 (0.54) | CA12CA9CA1CA2CA4 | |
| SCHEMBL4094195 | 0.84 | ELANE (0.40) | CA12CA9CA1CA2NFE2L2 | |
| SCHEMBL22471749 | 0.80 | CA1 (0.62) | CA12CA9CA1CA2CA4 | |
| SCHEMBL2599680 | 0.78 | CA1 (0.59) | CA12CA9CA1CA2CA4 | |
| SCHEMBL31475556 | 0.78 | CA1 (0.59) | CA12CA9CA1CA2CA4 | |
| SCHEMBL9451230 | 0.77 | CA2 (0.56) | CA12CA9CA1CA2CA4 | |
| SCHEMBL32665517 | 0.77 | ELANE (0.59) | CA12CA9CA1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 636 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119302921-A | Controlled release tablet of guaifenesin and preparation method thereof | 九华华源药业(桂林)有限公司 | 2025-01-14 | — | — | CN | claimed |
| CN-118252792-A | Compound paracetamol and guaifenesin oral solution and preparation method thereof | 海南倍特药业有限公司 | 2024-06-28 | — | — | CN | claimed |
| CN-116803376-B | Preparation method of compound guaiacol potassium sulfonate oral solution | 广州白云山星群(药业)股份有限公司 | 2024-02-13 | — | — | CN | claimed |
| CN-116803376-A | Compound guaiacol potassium sulfonate oral solution and preparation method thereof | 广州白云山星群(药业)股份有限公司 | 2023-09-26 | — | — | CN | claimed |
| CN-113813235-B | Preparation method of soluble guaiacol potassium sulfonate powder | 河南牧翔动物药业有限公司 | 2023-03-28 | — | — | CN | claimed |
| CN-115180584-A | Compound guaiacol potassium sulfonate oral solution nitrogen charging equipment | 福州海王金象中药制药有限公司 | 2022-10-14 | — | — | CN | claimed |
| US-11419938-B2 | Phenylephrine-containing liquid formulations | GLAXOSMITHKLINE CONSUMER HEALTHCARE HOLDINGS LLC (US) | 2022-08-23 | — | — | US | claimed |
| CN-113813235-A | Preparation method of soluble guaiacol potassium sulfonate powder | 河南牧翔动物药业有限公司 | 2021-12-21 | — | — | CN | claimed |
| CN-110229084-B | Preparation method of guaiacol potassium sulfonate | 广西两面针亿康药业股份有限公司 | 2021-09-21 | — | — | CN | claimed |
| CN-111135112-A | Wrinkle-removing anti-aging skin care composition and application thereof | 张传旋 | 2020-05-12 | — | — | CN | claimed |
| EP-1251874-A1 | STABILISED PHARMACEUTICAL COMPOSITIONS AND PROCESS FOR THEIR PREPARATION COMPRISING AN ANTIBIOTIC AND AN EXPECTORANT | New Pharma Research Sweden AB (SE) | 2002-10-30 | — | — | EP | claimed |
| WO-2001056610-A1 | STABILISED PHARMACEUTICAL COMPOSITIONS AND PROCESS FOR THEIR PREPARATION COMPRISING AN ANTIBIOTIC AND AN EXPECTORANT | NEW PHARMA RESEARCH SWEDEN AB (SE) | 2001-08-09 | — | — | WO | claimed |
| EP-0379147-B1 | Extrudable elastic gel for use as carrier for therapeutic agent | STERLING WINTHROP INC (US) | 1994-09-28 | — | — | EP | claimed |
| EP-0180597-B1 | COUGH/COLD MIXTURES COMPRISING NON-STEROIDAL ANTI-INFLAMMATORY DRUGS | RICHARDSON-VICKS, INC. (US) | 1992-03-04 | — | — | EP | claimed |
| EP-0379147-A2 | Extrudable elastic gel for use as carrier for therapeutic agent | STERLING WINTHROP INC. (US) | 1990-07-25 | — | — | EP | claimed |
| US-4738966-A | WITH EXPECTORANT | ANALGESIC ASSOCIATES (US) | 1988-04-19 | — | — | US | claimed |
| EP-0180597-A1 | COUGH/COLD MIXTURES COMPRISING NON-STEROIDAL ANTI-INFLAMMATORY DRUGS. | SUNSHINE ABRAHAM (US) | 1986-05-14 | — | — | EP | claimed |
| WO-1985004589-A1 | COUGH/COLD MIXTURES COMPRISING NON-STEROIDAL ANTI-INFLAMMATORY DRUGS | SUNSHINE ABRAHAM | 1985-10-24 | — | — | WO | claimed |
| US-4541987-A | GASTROINTESTINAL CANCER, REDOX SYSTEM | HELENA LABORATORIES CORPORATION (US) | 1985-09-17 | — | — | US | claimed |
| US-RE29875-E | THEOPHYLLINE SOLUBILIZED BY GLYCERYL GUAIACOLATE, POTASSIUM GUAIACOL SULFONATE OR GUAIACOL | MEAD JOHNSON & COMPANY (US) | 1979-01-02 | — | — | US | claimed |