Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | RARG | P13631 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | TPMT | P51580 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6838138 | 0.87 | RARG (0.39) | PTGS2ALDH1A1TSHRTDP1DHFR | |
| SCHEMBL1731694 | 0.79 | DHFR (0.38) | PTGS2ALDH1A1TSHRTDP1DHFR | |
| SCHEMBL1190206 | 0.79 | CA2 (0.38) | PTGS2ALDH1A1TSHRTDP1DHFR | |
| SCHEMBL2125454 | 0.79 | PTGS2 (0.35) | PTGS2ALDH1A1TSHRTDP1DHFR | |
| SCHEMBL351682 | 0.77 | PTGS2 (0.39) | PTGS2ALDH1A1TSHRTDP1DHFR | |
| SCHEMBL8247977 | 0.74 | TPMT (0.41) | TDP1CA1CA2RARGRXRA | |
| SCHEMBL482603 | 0.74 | DHFR (0.37) | PTGS2ALDH1A1TSHRTDP1DHFR | |
| SCHEMBL12678876 | 0.74 | PTGS2 (0.40) | PTGS2ALDH1A1TSHRTDP1DHFR | |
| SCHEMBL2947022 | 0.72 | PTGS2 (0.47) | PTGS2ALDH1A1TSHRTDP1DHFR | |
| SCHEMBL7878366 | 0.70 | CACNA1H (0.36) | TPMTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2444393-A1 | Methods for producing cyclic benzamidine derivatives | Eisai R&D Management Co., Ltd. (JP) | 2012-04-25 | — | — | EP | disclosed |
| WO-2011140936-A1 | 5,5-DISUBSTITUTED-2-IMINO-PYRROLIDINE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF | 上海恒瑞医药有限公司 (CN) | 2011-11-17 | — | — | WO | disclosed |
| US-7375236-B2 | Methods for producing cyclic benzamidine derivatives | EISAI CO., LTD. (JP) | 2008-05-20 | — | — | US | disclosed |
| US-7375236-B2 | Methods for producing cyclic benzamidine derivatives | EISAI CO., LTD. (JP) | 2008-05-20 | — | — | US | disclosed |
| US-7375236-B2 | Methods for producing cyclic benzamidine derivatives | EISAI CO., LTD. (JP) | 2008-05-20 | — | — | US | disclosed |
| US-20060058370-A1 | Methods for producing cyclic benzamidine derivatives | EISAI CO., LTD. (JP) | 2006-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060058370-A1 | Methods for producing cyclic benzamidine derivatives | DDC, DEK, HDHD5 | PTGS2 4634/4885ALDH1A1 2242/4885TSHR 2967/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.