Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 2/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.32 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24488175 | 0.90 | MEN1 (0.35) | PDE4BMEN1KMT2APDE4APDE4C | |
| SCHEMBL20331075 | 0.86 | MEN1 (0.33) | PDE4BMEN1KMT2AMAPTKDM4E | |
| SCHEMBL24488264 | 0.78 | P2RX3 (0.36) | KDM4EALDH1A1 | |
| SCHEMBL20331456 | 0.76 | MEN1 (0.41) | PDE4BMEN1KMT2AMAPTKDM4E | |
| SCHEMBL20330599 | 0.73 | MEN1 (0.38) | PDE4BMEN1KMT2AMAPTGAA | |
| SCHEMBL21251874 | 0.69 | FGFR4 (0.35) | PDE4BMEN1KMT2AMAPT | |
| SCHEMBL21251673 | 0.66 | P2RX3 (0.35) | — | |
| SCHEMBL24488280 | 0.64 | FGFR1 (0.33) | MEN1KMT2AALDH1A1 | |
| SCHEMBL18981723 | 0.64 | MEN1 (0.39) | MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL6206210 | 0.63 | KDM4E (0.31) | MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019242587-A1 | HIGHLY SELECTIVE FGFR I INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海和誉生物医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |