Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.31 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | ALPL | P05186 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21252130 | 0.88 | THRB (0.36) | MEN1KMT2AMAPTHPGDSTP53 | |
| SCHEMBL20330599 | 0.86 | MEN1 (0.38) | FGFR4MEN1KMT2APOLBMAPT | |
| SCHEMBL20331075 | 0.79 | MEN1 (0.33) | MEN1KMT2AMAPTHPGDSPDE4B | |
| SCHEMBL21252343 | 0.79 | MEN1 (0.43) | FGFR4MEN1KMT2APOLBMAPT | |
| SCHEMBL24488175 | 0.71 | MEN1 (0.35) | MEN1KMT2AMAPTHTTPDE4B | |
| SCHEMBL21252021 | 0.71 | MEN1 (0.44) | FGFR4MEN1KMT2AMAPTHTT | |
| SCHEMBL21602902 | 0.69 | FGFR4 (0.38) | FGFR4MEN1KMT2AHTTFGFR2 | |
| SCHEMBL21251963 | 0.69 | PDE4B (0.35) | MEN1KMT2AMAPTPDE4B | |
| SCHEMBL18981723 | 0.65 | MEN1 (0.39) | MEN1KMT2APOLBMAPT | |
| SCHEMBL20331772 | 0.65 | ALDH1A1 (0.46) | MEN1KMT2APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019242587-A1 | HIGHLY SELECTIVE FGFR I INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海和誉生物医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |