Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21251963 | 0.90 | PDE4B (0.35) | MEN1KMT2APDE4BMAPTKDM4E | |
| SCHEMBL20331075 | 0.89 | MEN1 (0.33) | MEN1KMT2APDE4BMAPTKDM4E | |
| SCHEMBL24488264 | 0.83 | P2RX3 (0.36) | KDM4EALDH1A1TSHRTDP1 | |
| SCHEMBL20331456 | 0.81 | MEN1 (0.41) | MEN1KMT2APDE4BMAPTKDM4E | |
| SCHEMBL20330599 | 0.80 | MEN1 (0.38) | MEN1KMT2APDE4BMAPTTSHR | |
| SCHEMBL21251874 | 0.71 | FGFR4 (0.35) | MEN1KMT2APDE4BMAPTHTT | |
| SCHEMBL21251673 | 0.66 | P2RX3 (0.35) | — | |
| SCHEMBL18981723 | 0.66 | MEN1 (0.39) | MEN1KMT2AMAPTALDH1A1TDP1 | |
| SCHEMBL25527232 | 0.65 | KDM4E (0.36) | MEN1KMT2APDE4BMAPTKDM4E | |
| SCHEMBL4770466 | 0.65 | MEN1 (0.38) | MEN1KMT2APDE4BMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-B1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | ABBISKO THERAPEUTICS CO LTD (CN) | 2022-06-08 | — | — | EP | disclosed |