Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | LPL | P06858 | 2/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20899463 | 0.85 | HTR2A (0.35) | EGFRHTR2AHTR2CHTR2BLPL | |
| SCHEMBL29012935 | 0.85 | LPL (0.38) | EGFRHTR2AHTR2CHTR2BLPL | |
| SCHEMBL26058390 | 0.85 | LPL (0.38) | EGFRLPLLIPGCSF1R | |
| SCHEMBL25245010 | 0.83 | EGFR (0.37) | EGFRLPLLIPGCSF1RNPSR1 | |
| SCHEMBL18152996 | 0.80 | LPL (0.41) | EGFRLPLLIPG | |
| SCHEMBL21296190 | 0.79 | ALDH1A1 (0.40) | LPLLIPGALDH1A1USP2KDM4E | |
| SCHEMBL30282902 | 0.79 | PDE4A (0.33) | LPLLIPGMCL1 | |
| SCHEMBL25153701 | 0.79 | PDE4A (0.33) | LPLLIPGMCL1 | |
| SCHEMBL30526881 | 0.79 | EGFR (0.37) | EGFRLPLLIPGALDH1A1CSF1R | |
| SCHEMBL18797560 | 0.78 | LPL (0.40) | EGFRLPLLIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11492354-B2 | Indazole compounds and uses thereof | INCYTE CORPORATION (US) | 2022-11-08 | — | — | US | disclosed |
| US-20210002288-A1 | INDAZOLE COMPOUNDS AND USES THEREOF | INCYTE CORPORATION | 2021-01-07 | — | — | US | disclosed |
| US-10752635-B2 | Indazole compounds and uses thereof | INCYTE CORPORATION (US) | 2020-08-25 | — | — | US | disclosed |
| WO-2019164847-A1 | INDAZOLE COMPOUNDS AND USES THEREOF | INCYTE CORPORATION (US) | 2019-08-29 | — | — | WO | disclosed |
| US-20190256520-A1 | INDAZOLE COMPOUNDS AND USES THEREOF | INCYTE CORPORATION | 2019-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210002288-A1 | INDAZOLE COMPOUNDS AND USES THEREOF | PDXK, PPIP5K2, PCK1 | EGFR 4515/4885HTR2A 4059/4885HTR2C 3854/4885 |
| US-10752635-B2 | Indazole compounds and uses thereof | PDXK, PPIP5K2, PCK1 | EGFR 4515/4885HTR2A 4059/4885HTR2C 3854/4885 |
| US-20190256520-A1 | INDAZOLE COMPOUNDS AND USES THEREOF | PDXK, PPIP5K2, PCK1 | EGFR 4515/4885HTR2A 4059/4885HTR2C 3854/4885 |
| US-11492354-B2 | Indazole compounds and uses thereof | PDXK, PPIP5K2, PCK1 | EGFR 4515/4885HTR2A 4059/4885HTR2C 3854/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.