Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | ESRRG | P62508 | 1/20 | 0.30 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21273356 | 0.78 | ALDH1A1 (0.44) | POLB | |
| SCHEMBL21273357 | 0.72 | MAPT (0.33) | — | |
| SCHEMBL21185076 | 0.67 | PI4KA (0.37) | — | |
| SCHEMBL31424338 | 0.67 | PI4KA (0.37) | — | |
| SCHEMBL619809 | 0.63 | MKNK1 (0.43) | POLB | |
| SCHEMBL30006645 | 0.63 | MKNK1 (0.43) | POLB | |
| Hydrochloric Acid SCHEMBL8102714 | 0.62 | MKNK1 (0.42) | POLB | |
| Hydrochloric Acid SCHEMBL1900003 | 0.62 | MKNK1 (0.42) | POLB | |
| SCHEMBL21608562 | 0.62 | PI4KA (0.38) | POLB | |
| SCHEMBL30861058 | 0.62 | PI4KA (0.38) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10745388-B2 | Indazole compounds and uses thereof | INCYTE CORPORATION (US) | 2020-08-18 | — | — | US | disclosed |
| US-10745388-B2 | Indazole compounds and uses thereof | INCYTE CORPORATION (US) | 2020-08-18 | — | — | US | disclosed |
| US-20190256500-A1 | INDAZOLE COMPOUNDS AND USES THEREOF | INCYTE CORPORATION | 2019-08-22 | — | — | US | disclosed |
| US-20190256500-A1 | INDAZOLE COMPOUNDS AND USES THEREOF | INCYTE CORPORATION | 2019-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10745388-B2 | Indazole compounds and uses thereof | PDXK, PPIP5K2, PCK1 | POLB 2180/4885TRPV1 4601/4885ESRRG 3630/4885 |
| US-20190256500-A1 | INDAZOLE COMPOUNDS AND USES THEREOF | PDXK, PPIP5K2, PCK1 | POLB 2180/4885TRPV1 4601/4885ESRRG 3630/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.