Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL378063 | 0.77 | P2RX7 (0.46) | — | |
| SCHEMBL4007003 | 0.75 | — | — | |
| SCHEMBL27972050 | 0.74 | P2RX7 (0.34) | — | |
| SCHEMBL986716 | 0.69 | P2RX7 (0.51) | — | |
| SCHEMBL29756950 | 0.68 | P2RX7 (0.38) | — | |
| SCHEMBL28854750 | 0.66 | ADAM10 (0.33) | — | |
| SCHEMBL23089828 | 0.66 | L3MBTL1 (0.31) | KCNH2HRH3MEN1KMT2ANPC1 | |
| SCHEMBL28275844 | 0.65 | TSHR (0.39) | MEN1KMT2ANPC1ALDH1A1ALOX15 | |
| SCHEMBL17397640 | 0.65 | MEN1 (0.39) | KCNH2HRH3MEN1KMT2ANPC1 | |
| SCHEMBL21840081 | 0.65 | ALDH1A1 (0.36) | KCNH2HRH3MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3752503-A1 | INHIBITORS OF TRPC6 | Boehringer Ingelheim International GmbH (DE) | 2020-12-23 | — | — | EP | disclosed |
| WO-2019161010-A1 | INHIBITORS OF TRPC6 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2019-08-22 | — | — | WO | disclosed |