Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.35 |
| ▸ | AURKA | O14965 | 6/20 | 0.35 |
| ▸ | CDK4 | P11802 | 6/20 | 0.35 |
| ▸ | INSR | P06213 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | OGA | O60502 | 1/20 | 0.32 |
| ▸ | SORD | Q00796 | 1/20 | 0.32 |
| ▸ | SMO | Q99835 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 2/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21285512 | 0.83 | KMT2A (0.43) | PARP1 | |
| SCHEMBL21274200 | 0.81 | GPR119 (0.42) | PARP1AURKACDK4INSRCDK1 | |
| SCHEMBL21274501 | 0.81 | GPR119 (0.42) | PARP1AURKACDK4INSRCDK1 | |
| SCHEMBL22801948 | 0.81 | GPR119 (0.42) | PARP1AURKACDK4INSRCDK1 | |
| SCHEMBL21268788 | 0.78 | AURKA (0.38) | AURKACDK4INSRCDK1PDGFRB | |
| SCHEMBL21281488 | 0.78 | AURKA (0.38) | AURKACDK4INSRCDK1PDGFRB | |
| SCHEMBL21274364 | 0.74 | DRD2 (0.43) | AURKACDK4 | |
| SCHEMBL21274365 | 0.74 | DRD2 (0.43) | AURKACDK4 | |
| SCHEMBL21281590 | 0.72 | PARP1 (0.36) | PARP1AURKACDK4INSRCDK1 | |
| SCHEMBL21285460 | 0.71 | AURKA (0.47) | PARP1AURKACDK4INSRCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019158731-A1 | PHARMACEUTICAL 6,5 HETEROBICYCLIC RING DERIVATIVES | UCB BIOPHARMA SPRL (BE) | 2019-08-22 | — | — | WO | disclosed |