SCHEMBL21291280

SCHEMBL21291280

Cc1cc(OCP(=O)(O)O)cc(I)c1Oc1ccc(O)c(C(C)C)c1

nearest known ligand 0.87

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
THRB P10828 18/20 0.87
THRA P10827 17/20 0.87

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL282588 0.93 THRB (1.00) THRBTHRA
SCHEMBL283081 0.92 THRA (1.00) THRBTHRA
SCHEMBL13381608 0.85 THRB (0.85) THRBTHRA
SCHEMBL13381659 0.84 THRA (0.84) THRBTHRA
SCHEMBL21291323 0.83 THRB (0.87) THRBTHRA
SCHEMBL13121902 0.83 THRB (0.85) THRBTHRA
SCHEMBL22072255 0.83 THRB (0.77) THRBTHRA
SCHEMBL18781621 0.83 THRA (0.71) THRBTHRA
SCHEMBL12825218 0.83 THRA (0.78) THRBTHRA
SCHEMBL21291313 0.82 THRA (0.77) THRBTHRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11707472-B2 Compositions for the treatment of fibrosis VIKING THERAPEUTICS, INC. (US) 2023-07-25 US disclosed
US-20220016136-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIVER DISORDERS VIKING THERAPEUTICS, INC. 2022-01-20 US disclosed
US-20200179412-A1 COMPOSITIONS FOR THE TREATMENT OF FIBROSIS VIKING THERAPEUTICS, INC. 2020-06-11 US disclosed
US-20190255080-A1 METHOD OF REDUCING THYROID-ASSOCIATED SIDE EFFECTS CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2019-08-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220016136-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIVER DISORDERS FABP1, SLC10A1, TSHR THRB 7/4885THRA 8/4885
US-11707472-B2 Compositions for the treatment of fibrosis COL2A1, TGFBR2, COL1A1 THRB 33/4885THRA 251/4885
US-20200179412-A1 COMPOSITIONS FOR THE TREATMENT OF FIBROSIS COL2A1, TGFBR2, COL1A1 THRB 33/4885THRA 251/4885
US-20190255080-A1 METHOD OF REDUCING THYROID-ASSOCIATED SIDE EFFECTS TSHR, TPO, THRA THRB 4/4885THRA 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.