Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | MDM4 | O15151 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL777274 | 0.82 | EPHX1 (0.38) | ACHEMAOAMAOBTAAR1CTSK | |
| SCHEMBL776700 | 0.78 | ACHE (0.43) | ACHEMAOAMAOBTAAR1CTSK | |
| SCHEMBL30833436 | 0.77 | HAO1 (0.42) | ACHEMAOAMAOBTAAR1CTSK | |
| SCHEMBL777766 | 0.77 | HAO1 (0.42) | ACHEMAOAMAOBTAAR1CTSK | |
| SCHEMBL24798532 | 0.77 | CYP3A4 (0.41) | MAOAMAOBCTSKTP53ALDH1A1 | |
| SCHEMBL29973024 | 0.77 | CYP3A4 (0.41) | MAOAMAOBCTSKTP53ALDH1A1 | |
| SCHEMBL13918976 | 0.77 | GRM5 (0.47) | MAOAMAOBTAAR1CTSKL3MBTL1 | |
| SCHEMBL10080198 | 0.74 | ALDH1A1 (0.52) | MAOAMAOBALDH1A1 | |
| SCHEMBL12933383 | 0.74 | MTNR1A (0.50) | ACHEMAOAMAOBALDH1A1 | |
| SCHEMBL5745166 | 0.74 | MAOA (0.40) | ACHEMAOAMAOBTAAR1CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190255055-A1 | SMALL MOLECULE INHIBITORS OF ALDH AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2019-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190255055-A1 | SMALL MOLECULE INHIBITORS OF ALDH AND USES THEREOF | ALDH2, ALDH1A1, ALDH3A1 | ACHE 2856/4885MAOA 1254/4885MAOB 1003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.