Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | MYC | P01106 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MPO | P05164 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3638609 | 0.88 | TRPA1 (0.46) | TRPA1ATMGABRA1GABRB2MEN1 | |
| Hydrochloric Acid SCHEMBL2965181 | 0.86 | TRPA1 (0.44) | TRPA1ATMGABRA1GABRB2MEN1 | |
| Water SCHEMBL10401166 | 0.86 | TRPA1 (0.44) | TRPA1ATMGABRA1GABRB2MEN1 | |
| Acetic Acid SCHEMBL1047016 | 0.85 | HPGD (0.40) | ATMGABRA1GABRB2MYCMEN1 | |
| Bicarbonate SCHEMBL5874331 | 0.79 | KMT2A (0.41) | ATMGABRA1GABRB2MYCMEN1 | |
| Acetic Acid SCHEMBL988127 | 0.78 | SLC9A1 (0.35) | — | |
| Acetic Acid SCHEMBL30560723 | 0.77 | TRPA1 (0.52) | TRPA1ATMMYCMEN1KMT2A | |
| Acetic Acid SCHEMBL3662435 | 0.77 | TRPA1 (0.52) | TRPA1ATMMYCMEN1KMT2A | |
| Oxalic Acid SCHEMBL5179301 | 0.77 | ALDH1A1 (0.44) | ATMGABRA1GABRB2MYCKMT2A | |
| Oxalic Acid SCHEMBL153610 | 0.77 | ALDH1A1 (0.44) | ATMGABRA1GABRB2MYCKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037951-B1 | PHOTOCHROMIC EPOXY RESIN COATING COMPOSITION | PPG IND OHIO INC (US) | 2005-11-16 | — | — | EP | claimed |
| US-6268055-B1 | CURED OVERCOATING | PPG INDUSTRIES OHIO, INC. | 2001-07-31 | — | — | US | claimed |
| EP-1037951-A1 | PHOTOCHROMIC EPOXY RESIN COATING COMPOSITION | PPG Industries Ohio, Inc. (US) | 2000-09-27 | — | — | EP | claimed |
| WO-1999029791-A1 | PHOTOCHROMIC EPOXY RESIN COATING COMPOSITION | PPG INDUSTRIES OHIO, INC. (US) | 1999-06-17 | — | — | WO | claimed |
| US-20240318031-A1 | WATERBORNE ACID-EPOXY COATING COMPOSITION | PPG INDUSTRIES OHIO, INC. (US) | 2024-09-26 | — | — | US | disclosed |
| EP-4271723-A1 | WATERBORNE ACID-EPOXY COATING COMPOSITION | PPG Industries Ohio Inc. (US) | 2023-11-08 | — | — | EP | disclosed |
| CN-116940614-A | Aqueous acid-epoxy resin coating composition | PPG工业俄亥俄公司 | 2023-10-24 | — | — | CN | disclosed |
| WO-2022147082-A1 | WATERBORNE ACID-EPOXY COATING COMPOSITION | PPG INDUSTRIES OHIO, INC. (US) | 2022-07-07 | — | — | WO | disclosed |
| EP-1952184-B1 | PHOTOCHROMIC MULTIFOCAL OPTICAL ARTICLE | TRANSITIONS OPTICAL INC (US) | 2021-08-11 | — | — | EP | disclosed |
| US-8742012-B2 | Thermosetting film-forming compositions that produce atrane-containing cured coatings | PPG INDUSTRIES OHIO, INC. (US) | 2014-06-03 | — | — | US | disclosed |
| WO-2014043434-A2 | POLYEPOXIDE-POLYACID COATING COMPOSITIONS, RELATED COATING PROCESSES AND COATED SUBSTRATES | PPG INDUSTRIES OHIO, INC. (US) | 2014-03-20 | — | — | WO | disclosed |
| US-20140072716-A1 | POLYEPOXIDE-POLYACID COATING COMPOSITIONS, RELATED COATING PROCESSES AND COATED SUBSTRATES | PPG INDUSTRIES OHIO, INC. (US) | 2014-03-13 | — | — | US | disclosed |
| EP-0305078-A2 | Process for preparing colour-plus-clear coated articles using high solids coating compositions containing a polyepoxide and a copolymer of an alpha-olefin and an olefinically unsaturated monoanhydride | PPG INDUSTRIES, INC. (US) | 1989-03-01 | — | — | EP | disclosed |
| US-4764430-A | Crosslinkable compositions containing polyepoxides and polyacid curing agents | PPG INDUSTRIES, INC. (US) | 1988-08-16 | — | — | US | disclosed |
| EP-0275138-A2 | Crosslinkable compositions containing polyepoxides and polyacid curing agents | PPG INDUSTRIES, INC. (US) | 1988-07-20 | — | — | EP | disclosed |
| US-4737403-A | PRIMER COMPRISING EPOXIDE-CONTAINING POLYMER AND POLYACID CURING AGENT | PPG INDUSTRIES, INC. (US) | 1988-04-12 | — | — | US | disclosed |
| US-4703101-A | COATINGS | PPG INDUSTRIES, INC. (US) | 1987-10-27 | — | — | US | disclosed |
| US-4681811-A | AUTOMOTIVE TOP COAT | PPG INDUSTRIES, INC. (US) | 1987-07-21 | — | — | US | disclosed |
| US-4650718-A | AUTOMOBILE FINISHES | PPG INDUSTRIES, INC. (US) | 1987-03-17 | — | — | US | disclosed |
| EP-0212457-A2 | Color plus clear coatings employing polyepoxides and polyacid curing agents in the clear coat | PPG INDUSTRIES, INC. (US) | 1987-03-04 | — | — | EP | disclosed |