SCHEMBL21295331

SCHEMBL21295331

Cc1ccc(NC(=O)Nc2ccc(Oc3ccccc3)c(C)c2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
STK39 Q9UEW8 1/20 0.56
MAPT P10636 5/20 0.52
MEN1 O00255 4/20 0.52
KMT2A Q03164 4/20 0.52
ALDH1A1 P00352 3/20 0.52
IDO1 P14902 4/20 0.52
DHODH Q02127 1/20 0.52
PGR P06401 1/20 0.51
AR P10275 1/20 0.51
NPC1 O15118 2/20 0.50
RAB9A P51151 2/20 0.50
IDH1 O75874 1/20 0.49
CDK8 P49336 1/20 0.49
KDR P35968 2/20 0.48
TEK Q02763 1/20 0.48
GAA P10253 2/20 0.48
PDGFRA P16234 1/20 0.48
KDM4E B2RXH2 1/20 0.48
POLB P06746 1/20 0.48
P2RY1 P47900 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21295431 0.94 STK39 (0.58) STK39MAPTMEN1KMT2AALDH1A1
SCHEMBL21305446 0.94 STK39 (0.60) STK39MAPTDHODHPGRAR
SCHEMBL30744028 0.94 STK39 (0.60) STK39MAPTDHODHPGRAR
SCHEMBL21295337 0.89 STK39 (0.54) STK39MAPTMEN1KMT2ADHODH
SCHEMBL30744002 0.89 STK39 (0.54) STK39MAPTMEN1KMT2ADHODH
SCHEMBL23051396 0.89 KMT2A (0.58) STK39MAPTMEN1KMT2AALDH1A1
SCHEMBL30743998 0.87 STK39 (0.57) STK39DHODHPGRARNPC1
SCHEMBL21295557 0.87 STK39 (0.57) STK39DHODHPGRARNPC1
SCHEMBL21295412 0.87 STK39 (0.62) STK39MAPTMEN1KMT2AALDH1A1
SCHEMBL21295385 0.85 TP53 (0.64) MAPTMEN1KMT2AALDH1A1PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250214948-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2025-07-03 US disclosed
CN-111819172-B Triazine derivatives for the treatment of neurotrophin related diseases 阿泽克制药公司 2024-02-06 CN disclosed
EP-3759088-B1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2023-01-25 EP disclosed
US-20220306589-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2022-09-29 US disclosed
US-11352332-B2 Triazine derivatives for treating diseases relating to neurotrophins AlzeCure Pharma AB (SE) 2022-06-07 US disclosed
US-11352332-B2 Triazine derivatives for treating diseases relating to neurotrophins AlzeCure Pharma AB (SE) 2022-06-07 US disclosed
EP-3759088-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS Alzecure Pharma AB (SE) 2021-01-06 EP disclosed
US-20200399230-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2020-12-24 US disclosed
US-20200399230-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2020-12-24 US disclosed
CN-111819172-A Triazine derivatives for the treatment of neurotrophin-related disorders 阿泽克制药公司 2020-10-23 CN disclosed
WO-2019162702-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2019-08-29 WO disclosed
WO-2019162702-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2019-08-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220306589-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS NTRK2, BDNF, NGF STK39 3105/4885MAPT 89/4885MEN1 2076/4885
US-20250214948-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS NTRK2, BDNF, NGF STK39 3105/4885MAPT 89/4885MEN1 2076/4885
US-11352332-B2 Triazine derivatives for treating diseases relating to neurotrophins NTRK2, BDNF, NGF STK39 3297/4885MAPT 79/4885MEN1 1771/4885
US-20200399230-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS NTRK2, BDNF, NGF STK39 3297/4885MAPT 79/4885MEN1 1771/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.