SCHEMBL21295339

SCHEMBL21295339

COc1ccc(NC(=O)Nc2ccc(Oc3ccccc3)c(OC)c2)cc1

nearest known ligand 0.63

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TP53 P04637 3/20 0.63
TSHR P16473 1/20 0.63
MCHR1 Q99705 2/20 0.61
RAB9A P51151 5/20 0.60
MAPT P10636 4/20 0.60
NPC1 O15118 3/20 0.60
SMN1; SMN2 Q16637 3/20 0.60
MEN1 O00255 5/20 0.60
KMT2A Q03164 5/20 0.60
PDGFRA P16234 3/20 0.59
KDR P35968 3/20 0.59
HIF1A Q16665 1/20 0.57
ALDH1A1 P00352 2/20 0.57
GAA P10253 1/20 0.56
MAPK1 P28482 1/20 0.56
RAF1 P04049 1/20 0.56
TTR P02766 1/20 0.56
KDM4E B2RXH2 1/20 0.55
CSF1R P07333 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21295536 0.94 KDR (0.61) TP53TSHRMCHR1RAB9AMAPT
SCHEMBL8348684 0.92 MCHR1 (0.67) TP53TSHRMCHR1RAB9AMAPT
SCHEMBL21295375 0.91 TP53 (0.66) TP53TSHRRAB9AMAPTNPC1
SCHEMBL30743987 0.91 TP53 (0.66) TP53TSHRRAB9AMAPTNPC1
SCHEMBL19427494 0.87 RAB9A (0.73) TP53TSHRRAB9AMAPTNPC1
SCHEMBL21295417 0.87 MCHR1 (0.59) TP53TSHRMCHR1RAB9AMAPT
SCHEMBL21295574 0.85 NPC1 (0.76) TP53TSHRRAB9AMAPTNPC1
SCHEMBL23292602 0.85 TP53 (0.58) TP53TSHRMCHR1RAB9AMAPT
SCHEMBL14384694 0.85 TTR (0.60) MCHR1RAB9AMAPTSMN1; SMN2MEN1
SCHEMBL8350552 0.84 KMT2A (0.72) TP53RAB9AMAPTNPC1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250214948-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2025-07-03 US disclosed
CN-111819172-B Triazine derivatives for the treatment of neurotrophin related diseases 阿泽克制药公司 2024-02-06 CN disclosed
EP-3759088-B1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2023-01-25 EP disclosed
US-20220306589-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2022-09-29 US disclosed
US-11352332-B2 Triazine derivatives for treating diseases relating to neurotrophins AlzeCure Pharma AB (SE) 2022-06-07 US disclosed
US-11352332-B2 Triazine derivatives for treating diseases relating to neurotrophins AlzeCure Pharma AB (SE) 2022-06-07 US disclosed
EP-3759088-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS Alzecure Pharma AB (SE) 2021-01-06 EP disclosed
US-20200399230-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2020-12-24 US disclosed
US-20200399230-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2020-12-24 US disclosed
CN-111819172-A Triazine derivatives for the treatment of neurotrophin-related disorders 阿泽克制药公司 2020-10-23 CN disclosed
WO-2019162702-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2019-08-29 WO disclosed
WO-2019162702-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS AlzeCure Pharma AB (SE) 2019-08-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220306589-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS NTRK2, BDNF, NGF TP53 2873/4885TSHR 144/4885MCHR1 321/4885
US-20250214948-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS NTRK2, BDNF, NGF TP53 2873/4885TSHR 144/4885MCHR1 321/4885
US-11352332-B2 Triazine derivatives for treating diseases relating to neurotrophins NTRK2, BDNF, NGF TP53 2709/4885TSHR 123/4885MCHR1 317/4885
US-20200399230-A1 TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS NTRK2, BDNF, NGF TP53 2709/4885TSHR 123/4885MCHR1 317/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.