Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 8/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | KDM5A | P29375 | 2/20 | 0.35 |
| ▸ | KDM3A | Q9Y4C1 | 2/20 | 0.35 |
| ▸ | JMJD1C | Q15652 | 1/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 6/20 | 0.35 |
| ▸ | ECE1 | P42892 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.34 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.33 |
| ▸ | STK4 | Q13043 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM6B | O15054 | 1/20 | 0.33 |
| ▸ | TET3 | O43151 | 1/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KDM5C | P41229 | 1/20 | 0.33 |
| ▸ | ASPH | Q12797 | 1/20 | 0.33 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26058396 | 0.91 | MAP4K1 (0.38) | XDHKDM4EKDM5AKDM3AJMJD1C | |
| SCHEMBL21309140 | 0.80 | XDH (0.35) | XDHKDM4EKDM5AKDM3AJMJD1C | |
| SCHEMBL21271946 | 0.77 | KDM4E (0.39) | XDHKDM4EKDM5AKDM3AJMJD1C | |
| SCHEMBL320207 | 0.76 | KDM4E (0.47) | XDHKDM4EKDM5AKDM3AJMJD1C | |
| SCHEMBL21681229 | 0.76 | XDH (0.38) | XDHKDM4EMAP4K1ECE1NTRK1 | |
| SCHEMBL21271882 | 0.75 | MAP4K1 (0.55) | MAP4K1NTRK1MAP4K2STK4 | |
| SCHEMBL21681168 | 0.75 | KDM4E (0.46) | XDHKDM4EMAP4K1ECE1NTRK1 | |
| SCHEMBL29572632 | 0.75 | MAP4K1 (0.55) | MAP4K1NTRK1MAP4K2STK4 | |
| SCHEMBL21681186 | 0.73 | XDH (0.53) | XDHMAP4K1ECE1ALDH1A1 | |
| SCHEMBL25258964 | 0.70 | XDH (0.52) | XDHKDM4EL3MBTL1ALDH1A1KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12466815-B2 | Carboxamide compounds and uses thereof | INCYTE CORPORATION (US) | 2025-11-11 | — | — | US | disclosed |
| US-20240150326-A1 | CARBOXAMIDE COMPOUNDS AND USES THEREOF | INCYTE CORPORATION | 2024-05-09 | — | — | US | disclosed |
| US-11731958-B2 | Carboxamide compounds and uses thereof | INCYTE CORPORATION (US) | 2023-08-22 | — | — | US | disclosed |
| EP-3755703-B1 | N-(PHENYL)-2-(PHENYL)PYRIMIDINE-4-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS HPK1 INHIBITORS FOR TREATING CANCER | INCYTE CORP (US) | 2022-05-04 | — | — | EP | disclosed |
| US-20210094934-A1 | CARBOXAMIDE COMPOUNDS AND USES THEREOF | INCYTE CORPORATION | 2021-04-01 | — | — | US | disclosed |
| EP-3755703-A1 | N-(PHENYL)-2-(PHENYL)PYRIMIDINE-4-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS HPK1 INHIBITORS FOR TREATING CANCER | Incyte Corporation (US) | 2020-12-30 | — | — | EP | disclosed |
| US-10800761-B2 | Carboxamide compounds and uses thereof | INCYTE CORPORATION (US) | 2020-10-13 | — | — | US | disclosed |
| WO-2019164846-A1 | N-(PHENYL)-2-(PHENYL)PYRIMIDINE-4-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS HPK1 INHIBITORS FOR TREATING CANCER | INCYTE CORPORATION (US) | 2019-08-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10800761-B2 | Carboxamide compounds and uses thereof | PCK1, PHKG2, PHKG1 | XDH 416/4885KDM4E 1788/4885KDM5A 1886/4885 |
| US-11731958-B2 | Carboxamide compounds and uses thereof | PCK1, PHKG2, PHKG1 | XDH 416/4885KDM4E 1788/4885KDM5A 1886/4885 |
| US-20240150326-A1 | CARBOXAMIDE COMPOUNDS AND USES THEREOF | PCK1, PHKG2, PHKG1 | XDH 416/4885KDM4E 1788/4885KDM5A 1886/4885 |
| US-20210094934-A1 | CARBOXAMIDE COMPOUNDS AND USES THEREOF | PCK1, PHKG2, PHKG1 | XDH 416/4885KDM4E 1788/4885KDM5A 1886/4885 |
| US-12466815-B2 | Carboxamide compounds and uses thereof | PCK1, PHKG2, PHKG1 | XDH 416/4885KDM4E 1788/4885KDM5A 1886/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.