Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 10/20 | 0.62 |
| ▸ | HSD17B2 | P37059 | 9/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | RXRA | P19793 | 1/20 | 0.55 |
| ▸ | RXRB | P28702 | 1/20 | 0.55 |
| ▸ | ESR1 | P03372 | 2/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | BCR | P11274 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31544769 | 1.00 | HSD17B1 (0.62) | HSD17B1HSD17B2CYP3A4CYP2C9TSHR | |
| SCHEMBL1029061 | 0.88 | TSHR (0.73) | HSD17B1HSD17B2CYP3A4CYP2C9TSHR | |
| SCHEMBL23808908 | 0.86 | HSD17B1 (0.52) | HSD17B1HSD17B2CYP3A4CYP2C9TSHR | |
| SCHEMBL31054285 | 0.83 | HSD17B1 (0.79) | HSD17B1HSD17B2CYP3A4CYP2C9ESR1 | |
| SCHEMBL25561343 | 0.83 | HSD17B1 (0.79) | HSD17B1HSD17B2CYP3A4CYP2C9ESR1 | |
| SCHEMBL1959838 | 0.83 | RXRA (0.59) | CYP3A4CYP2C9TSHRRXRARXRB | |
| SCHEMBL69369 | 0.83 | HSD17B1 (0.88) | HSD17B1HSD17B2CYP3A4CYP2C9ESR1 | |
| SCHEMBL29551999 | 0.83 | HSD17B1 (0.88) | HSD17B1HSD17B2CYP3A4CYP2C9ESR1 | |
| SCHEMBL1028579 | 0.82 | HSD17B1 (0.77) | HSD17B1HSD17B2CYP3A4CYP2C9TSHR | |
| SCHEMBL5037644 | 0.81 | HSD17B1 (0.68) | HSD17B1HSD17B2CYP3A4CYP2C9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11389456-B2 | Compounds and methods for treating oxalate-related diseases | OXALURX, INC. (US) | 2022-07-19 | — | — | US | disclosed |
| CN-112384509-A | Furin inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2021-02-19 | — | — | CN | disclosed |
| US-20200390778-A1 | COMPOUNDS AND METHODS FOR TREATING OXALATE-RELATED DISEASES | OXALURX, INC. | 2020-12-17 | — | — | US | disclosed |
| WO-2019165159-A1 | COMPOUNDS AND METHODS FOR TREATING OXALATE-RELATED DISEASES | OXALURX, INC. (US) | 2019-08-29 | — | — | WO | disclosed |
| CN-105555761-B | Biphenyl derivatives and process for preparing the same | 东亚ST 株式会社 | 2018-12-11 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200390778-A1 | COMPOUNDS AND METHODS FOR TREATING OXALATE-RELATED DISEASES | XDH, PNPO, LOX | HSD17B1 553/4885HSD17B2 821/4885CYP3A4 2004/4885 |
| US-11389456-B2 | Compounds and methods for treating oxalate-related diseases | XDH, PNPO, LOX | HSD17B1 553/4885HSD17B2 821/4885CYP3A4 2004/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.