Sugi Predict

Sugi Predict / Compounds / SCHEMBL21296949

SCHEMBL21296949

SCHEMBL21296949

Cc1ccc(-c2ccc(Sc3[nH]nnc3C(=O)O)cc2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALPL P05186 2/20 0.42
▸ ALDH1A1 P00352 3/20 0.39
▸ SMN1; SMN2 Q16637 3/20 0.39
▸ GAA P10253 1/20 0.39
▸ KDM4E B2RXH2 1/20 0.39
▸ USP2 O75604 1/20 0.39
▸ HPGD P15428 1/20 0.39
▸ HSD17B10 Q99714 1/20 0.39
▸ MCL1 Q07820 1/20 0.36
▸ MAPK1 P28482 1/20 0.35
▸ MAP2K4 P45985 1/20 0.35
▸ MAPKAPK3 Q16644 1/20 0.35
▸ MAPK6 Q16659 1/20 0.35
▸ RXRA P19793 1/20 0.35
▸ RXRB P28702 1/20 0.35
▸ HAO1 Q9UJM8 1/20 0.35
▸ MAP4K4 O95819 1/20 0.35
▸ TYMP P19971 1/20 0.35
▸ ICAM1 P05362 1/20 0.34
▸ SELE P16581 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21296965 0.96 SMN1; SMN2 (0.41) ALPLALDH1A1SMN1; SMN2GAAKDM4E
SCHEMBL21312388 0.89 HAO1 (0.38) MCL1HAO1CTRC
SCHEMBL21296860 0.88 KDM4E (0.38) KDM4EHPGDMAPK1HAO1RAB9A
SCHEMBL21312724 0.86 ALPL (0.45) ALPLALDH1A1KDM4EMAPK1MAP2K4
SCHEMBL21312707 0.86 RHEB (0.39) ALDH1A1HPGDMCL1HAO1CTRC
SCHEMBL21312773 0.86 HAO1 (0.50) ALPLSMN1; SMN2KDM4EMAP2K4RXRA
SCHEMBL24154469 0.85 RXRA (0.37) USP2MCL1RXRARXRBHAO1
SCHEMBL21312777 0.85 PRKAG1 (0.48) ALPLALDH1A1SMN1; SMN2KDM4ERXRA
SCHEMBL21312351 0.84 HAO1 (0.40) ALDH1A1KDM4EHAO1
SCHEMBL21312821 0.84 HAO1 (0.37) ALDH1A1SMN1; SMN2KDM4EHPGDHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230143491-A1 TRIAZOLE GLYCOLATE OXIDASE INHIBITORS PHOENIX TISSUE REPAIR, INC. 2023-05-11 — — US disclosed
US-11389456-B2 Compounds and methods for treating oxalate-related diseases OXALURX, INC. (US) 2022-07-19 — — US disclosed
US-20200390778-A1 COMPOUNDS AND METHODS FOR TREATING OXALATE-RELATED DISEASES OXALURX, INC. 2020-12-17 — — US disclosed
US-20200390778-A1 COMPOUNDS AND METHODS FOR TREATING OXALATE-RELATED DISEASES OXALURX, INC. 2020-12-17 — — US disclosed
WO-2019165159-A1 COMPOUNDS AND METHODS FOR TREATING OXALATE-RELATED DISEASES OXALURX, INC. (US) 2019-08-29 — — WO disclosed
WO-2019165159-A1 COMPOUNDS AND METHODS FOR TREATING OXALATE-RELATED DISEASES OXALURX, INC. (US) 2019-08-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230143491-A1 TRIAZOLE GLYCOLATE OXIDASE INHIBITORS XDH, DUOX1, PNPO ALPL 652/4885ALDH1A1 262/4885SMN1; SMN2 4805/4885
US-20200390778-A1 COMPOUNDS AND METHODS FOR TREATING OXALATE-RELATED DISEASES XDH, PNPO, LOX ALPL 576/4885ALDH1A1 543/4885SMN1; SMN2 3163/4885
US-11389456-B2 Compounds and methods for treating oxalate-related diseases XDH, PNPO, LOX ALPL 576/4885ALDH1A1 543/4885SMN1; SMN2 3163/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.