SCHEMBL21297899

SCHEMBL21297899

N#Cc1nc2c3ccc4ccccc4c3c3nc(C#N)c(C#N)nc3c2nc1C#N

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPRT1 P00492 1/20 0.39
ALOX15 P16050 6/20 0.38
HSD17B10 Q99714 5/20 0.38
HPGD P15428 4/20 0.38
TSHR P16473 4/20 0.38
CASP1 P29466 4/20 0.38
CASP7 P55210 4/20 0.38
CYP3A4 P08684 2/20 0.38
RAB9A P51151 2/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
MAPK1 P28482 1/20 0.38
ATM Q13315 1/20 0.38
HIF1A Q16665 1/20 0.38
CA1 P00915 2/20 0.38
CA2 P00918 2/20 0.38
USP8 P40818 1/20 0.38
USP7 Q93009 1/20 0.38
USP47 Q96K76 1/20 0.38
ALDH1A1 P00352 9/20 0.37
KDM4E B2RXH2 7/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21297892 0.95 HPRT1 (0.38) HPRT1ALOX15HSD17B10HPGDTSHR
SCHEMBL21298365 0.94 ALDH1A1 (0.39) HPRT1ALOX15HSD17B10HPGDTSHR
SCHEMBL21298001 0.94 ALDH1A1 (0.39) HPRT1ALOX15HSD17B10HPGDTSHR
SCHEMBL21297903 0.93 HPRT1 (0.41) HPRT1ALOX15HSD17B10HPGDTSHR
SCHEMBL21297896 0.93 HPRT1 (0.41) HPRT1ALOX15HSD17B10HPGDTSHR
SCHEMBL21297905 0.92 HPRT1 (0.42) HPRT1ALOX15HSD17B10HPGDTSHR
SCHEMBL21298002 0.90 KDM4E (0.33) HPRT1ALOX15HSD17B10HPGDTSHR
SCHEMBL21298372 0.90 KDM4E (0.33) HPRT1ALOX15HSD17B10HPGDTSHR
SCHEMBL21297959 0.90 HPRT1 (0.39) HPRT1ALOX15HSD17B10HPGDTSHR
SCHEMBL21297900 0.89 HPRT1 (0.39) HPRT1ALOX15HSD17B10HPGDTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230192695-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS UNIV ARIZONA STATE (US) 2023-06-22 US disclosed
US-20210024526-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS UNITED STATES DEPARTMENT OF ENERGY 2021-01-28 US disclosed
US-10851106-B2 Substituted benzo[4,5]imidazo[1,2-F]phenanthridines, dibenzo[I.K]benzo[4,5]imidazo[1,2-F]benzofurophenanthridines and dibenzo[I.K]benzo[4,5]imidazo[1,2-F]benzo[4,5]thienophenanthridines as thermally assisted delayed fluorescent materials ARIZONA BOARD OF REGENTS, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2020-12-01 US disclosed
US-20200071330-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS UNITED STATES DEPARTMENT OF ENERGY 2020-03-05 US disclosed
US-10392387-B2 Substituted benzo[4,5]imidazo[1,2-a]phenanthro[9,10-c][1,8]naphthyridines, benzo[4,5]imidazo[1,2-a]phenanthro[9,10-c][1,5]naphthyridines and dibenzo[f,h]benzo[4,5]imidazo[2,1-a]pyrazino[2,3-c]isoquinolines as thermally assisted delayed fluorescent materials ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2019-08-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210024526-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS TTPA, TTC14, AAAS HPRT1 884/4885ALOX15 4406/4885HSD17B10 3931/4885
US-20200071330-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS TTPA, TTC14, AAAS HPRT1 884/4885ALOX15 4406/4885HSD17B10 3931/4885
US-20230192695-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS TTPA, TTC14, AAAS HPRT1 884/4885ALOX15 4406/4885HSD17B10 3931/4885
US-10851106-B2 Substituted benzo[4,5]imidazo[1,2-F]phenanthridines, dibenzo[I.K]benzo[4,5]imidazo[1,2-F]benzofurophenanthridines and dibenzo[I.K]benzo[4,5]imidazo[1,2-F]benzo[4,5]thienophenanthridines as thermally assisted delayed fluorescent materials KCNK4, TRPC4, TBRG4 HPRT1 1791/4885ALOX15 4349/4885HSD17B10 3165/4885
US-10392387-B2 Substituted benzo[4,5]imidazo[1,2-a]phenanthro[9,10-c][1,8]naphthyridines, benzo[4,5]imidazo[1,2-a]phenanthro[9,10-c][1,5]naphthyridines and dibenzo[f,h]benzo[4,5]imidazo[2,1-a]pyrazino[2,3-c]isoquinolines as thermally assisted delayed fluorescent materials NT5C, HTR3D, IK HPRT1 1235/4885ALOX15 3698/4885HSD17B10 3563/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.