SCHEMBL21297904

SCHEMBL21297904

N#Cc1nc2c3cc4c(C#N)c(C#N)c(C#N)c(C#N)c4cc3c3c4ccccc4ccc3c2nc1C#N

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.37
ALDH1A1 P00352 5/20 0.37
HPGD P15428 3/20 0.37
MEN1 O00255 3/20 0.37
GAA P10253 3/20 0.37
KMT2A Q03164 3/20 0.37
MAPT P10636 3/20 0.37
CYP3A4 P08684 2/20 0.37
CYP1A2 P05177 1/20 0.37
CA1 P00915 2/20 0.35
CA2 P00918 2/20 0.35
ANPEP P15144 1/20 0.34
PIM1 P11309 2/20 0.34
ALOX15 P16050 3/20 0.33
USP8 P40818 1/20 0.32
USP7 Q93009 1/20 0.32
USP47 Q96K76 1/20 0.32
L3MBTL1 Q9Y468 3/20 0.32
TSHR P16473 2/20 0.32
CASP1 P29466 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21298367 0.90 KDM4E (0.36) KDM4EALDH1A1HPGDMEN1GAA
SCHEMBL21297917 0.88 CA1 (0.38) KDM4EALDH1A1HPGDMEN1GAA
SCHEMBL21297764 0.86 CYP3A4 (0.37) KDM4EALDH1A1HPGDMEN1GAA
SCHEMBL21298127 0.86 KDM4E (0.40) KDM4EALDH1A1HPGDMEN1GAA
SCHEMBL21297959 0.84 HPRT1 (0.39) KDM4EALDH1A1HPGDMEN1GAA
SCHEMBL21297903 0.83 HPRT1 (0.41) KDM4EALDH1A1HPGDMEN1GAA
SCHEMBL21298473 0.83 ALDH1A1 (0.39) KDM4EALDH1A1HPGDMEN1GAA
SCHEMBL21298433 0.83 KDM4E (0.38) KDM4EALDH1A1MEN1GAAKMT2A
SCHEMBL21298056 0.82 KDM4E (0.38) KDM4EALDH1A1MEN1GAAKMT2A
SCHEMBL21297892 0.82 HPRT1 (0.38) KDM4EALDH1A1HPGDMEN1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230192695-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS UNIV ARIZONA STATE (US) 2023-06-22 US disclosed
US-20210024526-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS UNITED STATES DEPARTMENT OF ENERGY 2021-01-28 US disclosed
US-10851106-B2 Substituted benzo[4,5]imidazo[1,2-F]phenanthridines, dibenzo[I.K]benzo[4,5]imidazo[1,2-F]benzofurophenanthridines and dibenzo[I.K]benzo[4,5]imidazo[1,2-F]benzo[4,5]thienophenanthridines as thermally assisted delayed fluorescent materials ARIZONA BOARD OF REGENTS, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2020-12-01 US disclosed
US-20200071330-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS UNITED STATES DEPARTMENT OF ENERGY 2020-03-05 US disclosed
US-10392387-B2 Substituted benzo[4,5]imidazo[1,2-a]phenanthro[9,10-c][1,8]naphthyridines, benzo[4,5]imidazo[1,2-a]phenanthro[9,10-c][1,5]naphthyridines and dibenzo[f,h]benzo[4,5]imidazo[2,1-a]pyrazino[2,3-c]isoquinolines as thermally assisted delayed fluorescent materials ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2019-08-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210024526-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS TTPA, TTC14, AAAS KDM4E 3740/4885ALDH1A1 2839/4885HPGD 1924/4885
US-20200071330-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS TTPA, TTC14, AAAS KDM4E 3740/4885ALDH1A1 2839/4885HPGD 1924/4885
US-20230192695-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS TTPA, TTC14, AAAS KDM4E 3740/4885ALDH1A1 2839/4885HPGD 1924/4885
US-10851106-B2 Substituted benzo[4,5]imidazo[1,2-F]phenanthridines, dibenzo[I.K]benzo[4,5]imidazo[1,2-F]benzofurophenanthridines and dibenzo[I.K]benzo[4,5]imidazo[1,2-F]benzo[4,5]thienophenanthridines as thermally assisted delayed fluorescent materials KCNK4, TRPC4, TBRG4 KDM4E 731/4885ALDH1A1 566/4885HPGD 2166/4885
US-10392387-B2 Substituted benzo[4,5]imidazo[1,2-a]phenanthro[9,10-c][1,8]naphthyridines, benzo[4,5]imidazo[1,2-a]phenanthro[9,10-c][1,5]naphthyridines and dibenzo[f,h]benzo[4,5]imidazo[2,1-a]pyrazino[2,3-c]isoquinolines as thermally assisted delayed fluorescent materials NT5C, HTR3D, IK KDM4E 2046/4885ALDH1A1 326/4885HPGD 1744/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.