Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18724210 | 0.85 | MAPK1 (0.42) | MAPK1ALDH1A1CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL21005887 | 0.77 | CRHR1 (0.38) | CRHR1 | |
| SCHEMBL21301026 | 0.77 | CRHR1 (0.40) | MAPK1ALDH1A1CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL21301073 | 0.76 | MAPK1 (0.43) | MAPK1ALDH1A1CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL18724169 | 0.76 | MAPT (0.39) | CRHBPCRHR2SMN1; SMN2CRHR1HTR2A | |
| SCHEMBL21300927 | 0.74 | MAPK1 (0.44) | MAPK1ALDH1A1CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL21301076 | 0.73 | MAPT (0.43) | ALDH1A1CRHBPCRHR2SMN1; SMN2CRHR1 | |
| SCHEMBL21301159 | 0.73 | CRHR1 (0.50) | ALDH1A1CRHR1HTR2ALRRK2 | |
| SCHEMBL21301035 | 0.72 | CRHR1 (0.44) | MAPK1ALDH1A1CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL21005959 | 0.71 | MEN1 (0.47) | ALDH1A1CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2963036-B1 | 2-ACYLAMINOTHIAZOLE DERIVATIVE AND SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2019-08-28 | — | — | EP | disclosed |