Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.42 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18724169 | 0.97 | MAPT (0.39) | MAPTCRHBPCRHR2SMN1; SMN2S1PR1 | |
| SCHEMBL21300929 | 0.91 | S1PR1 (0.36) | MAPTCRHBPCRHR2SMN1; SMN2S1PR1 | |
| SCHEMBL18724292 | 0.89 | CTSS (0.39) | S1PR1CRHR1 | |
| SCHEMBL18724210 | 0.88 | MAPK1 (0.42) | MAPTCRHBPCRHR2SMN1; SMN2S1PR1 | |
| SCHEMBL21006251 | 0.87 | PDE3B (0.40) | S1PR1 | |
| SCHEMBL21300945 | 0.87 | KMO (0.49) | MAPTS1PR1KMOACHECRHR1 | |
| SCHEMBL18724370 | 0.86 | ACHE (0.41) | MAPTCRHBPCRHR2SMN1; SMN2S1PR1 | |
| SCHEMBL21301089 | 0.85 | ACHE (0.42) | MAPTS1PR1KMOACHE | |
| SCHEMBL21005922 | 0.85 | MPL (0.43) | MAPTACHECRHR1 | |
| SCHEMBL18724299 | 0.84 | CRHR1 (0.35) | ACHEKMT2ACRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2963036-B1 | 2-ACYLAMINOTHIAZOLE DERIVATIVE AND SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2019-08-28 | — | — | EP | disclosed |