Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 1/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.36 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.36 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18724210 | 0.85 | MAPK1 (0.42) | CRHR1ACHEALDH1A1KMOHTR2A | |
| SCHEMBL18724169 | 0.82 | MAPT (0.39) | CRHR1ACHEKMOHTR2A | |
| SCHEMBL21301073 | 0.81 | MAPK1 (0.43) | CRHR1GRM2KDM4EALDH1A1KMO | |
| SCHEMBL21301076 | 0.80 | MAPT (0.43) | CRHR1ACHEKDM4EALDH1A1KMO | |
| SCHEMBL21301026 | 0.80 | CRHR1 (0.40) | CRHR1SPHK2ALDH1A1 | |
| SCHEMBL17400643 | 0.79 | MPL (0.47) | CRHR1 | |
| SCHEMBL21300943 | 0.79 | CTSS (0.44) | CRHR1ACHEALDH1A1KMOHTR2A | |
| SCHEMBL21005887 | 0.78 | CRHR1 (0.38) | CRHR1SPHK2 | |
| SCHEMBL21300927 | 0.77 | MAPK1 (0.44) | CRHR1ALDH1A1KMO | |
| SCHEMBL21301082 | 0.77 | HTR2A (0.35) | CRHR1ACHESPHK2KMOHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2963036-B1 | 2-ACYLAMINOTHIAZOLE DERIVATIVE AND SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2019-08-28 | — | — | EP | disclosed |