Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | CTSS | P25774 | 2/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 4/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | MPL | P40238 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21300943 | 0.89 | CTSS (0.44) | KMOHTR2ACTSSS1PR1TRPV4 | |
| SCHEMBL21300945 | 0.88 | KMO (0.49) | KMOHTR2ACTSSS1PR1TRPV4 | |
| SCHEMBL21301089 | 0.85 | ACHE (0.42) | KMOHTR2AS1PR1TRPV4ACHE | |
| SCHEMBL18724169 | 0.84 | MAPT (0.39) | KMOHTR2ACTSSS1PR1ACHE | |
| SCHEMBL18724210 | 0.82 | MAPK1 (0.42) | KMOHTR2ACTSSS1PR1ACHE | |
| SCHEMBL21301076 | 0.82 | MAPT (0.43) | KMOS1PR1ACHEKMT2A | |
| SCHEMBL21301065 | 0.81 | KMO (0.41) | KMOCTSSS1PR1TRPV4ACHE | |
| SCHEMBL21300934 | 0.79 | KMO (0.40) | KMOHTR2ACTSSS1PR1TRPV4 | |
| SCHEMBL17400686 | 0.79 | MPL (0.50) | S1PR1TRPV4MPL | |
| SCHEMBL21301082 | 0.79 | HTR2A (0.35) | KMOHTR2ACTSSS1PR1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2963036-B1 | 2-ACYLAMINOTHIAZOLE DERIVATIVE AND SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2019-08-28 | — | — | EP | disclosed |