Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 2/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.30 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16637427 | 0.85 | MAPT (0.41) | MAPTGABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL22960801 | 0.85 | MAPT (0.39) | MAPTGABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL16268180 | 0.85 | GABRG2 (0.38) | MAPTGABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL21310437 | 0.79 | AAK1 (0.39) | MAPTGABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL23010089 | 0.77 | GABRG2 (0.38) | MAPTGABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL19805011 | 0.76 | GABRG2 (0.37) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL16637537 | 0.76 | GABRG2 (0.37) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL19806740 | 0.73 | DDB1 (0.42) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL16268476 | 0.71 | HIPK2 (0.33) | MAPT | |
| SCHEMBL16268477 | 0.71 | HIPK2 (0.33) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210047327-A1 | DIAGNOSTIC COMPOSITIONS FOR PET IMAGING, A METHOD FOR MANUFACTURING THE DIAGNOSTIC COMPOSITION AND ITS USE IN DIAGNOSTICS | LIFE MOLECULAR IMAGING LIMITED (GB) | 2021-02-18 | — | — | US | disclosed |
| US-10865207-B2 | Compounds for imaging Tau protein aggregates | AC IMMUNE S.A. (CH) | 2020-12-15 | — | — | US | disclosed |
| US-10835624-B2 | Compounds for imaging Tau protein aggregates | AC IMMUNE S.A. (CH) | 2020-11-17 | — | — | US | disclosed |
| US-20190262480-A1 | COMPOUNDS FOR IMAGING TAU PROTEIN AGGREGATES | Lantheus Biosciences Ltd. (GB) | 2019-08-29 | — | — | US | disclosed |
| US-20190263817-A1 | COMPOUNDS FOR IMAGING TAU PROTEIN AGGREGATES | Lantheus Biosciences Ltd. (GB) | 2019-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190262480-A1 | COMPOUNDS FOR IMAGING TAU PROTEIN AGGREGATES | MAPT, PSEN2, PSEN1 | MAPT 1/4885GABRG2 2609/4885GABRB3 1875/4885 |
| US-10835624-B2 | Compounds for imaging Tau protein aggregates | MAPT, PSEN2, PSEN1 | MAPT 1/4885GABRG2 2609/4885GABRB3 1875/4885 |
| US-20210047327-A1 | DIAGNOSTIC COMPOSITIONS FOR PET IMAGING, A METHOD FOR MANUFACTURING THE DIAGNOSTIC COMPOSITION AND ITS USE IN DIAGNOSTICS | MAPT, PSEN1, APP | MAPT 1/4885GABRG2 1520/4885GABRB3 1204/4885 |
| US-10865207-B2 | Compounds for imaging Tau protein aggregates | MAPT, PSEN1, PSEN2 | MAPT 1/4885GABRG2 2766/4885GABRB3 1947/4885 |
| US-20190263817-A1 | COMPOUNDS FOR IMAGING TAU PROTEIN AGGREGATES | MAPT, PSEN1, PSEN2 | MAPT 1/4885GABRG2 2766/4885GABRB3 1947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.