Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 10/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6855553 | 0.82 | TEAD3 (0.58) | KDM4EALDH1A1LMNATEAD3SIGMAR1 | |
| SCHEMBL21243820 | 0.77 | HTT (0.59) | KDM4EALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6949170 | 0.75 | ALDH1A1 (0.55) | ALDH1A1LMNASMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL2896415 | 0.74 | SMN1; SMN2 (0.76) | NPC1RAB9ASMN1; SMN2HTTNPSR1 | |
| SCHEMBL1222524 | 0.73 | ALDH1A1 (0.59) | KDM4EALDH1A1LMNASIGMAR1GAA | |
| SCHEMBL26024996 | 0.73 | MEN1 (0.50) | ALDH1A1TEAD3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6640789 | 0.73 | LMNA (0.64) | ALDH1A1LMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12230203 | 0.73 | ALDH1A1 (0.52) | ALDH1A1LMNASMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL6942319 | 0.72 | TEAD3 (0.56) | KDM4EALDH1A1LMNATEAD3SIGMAR1 | |
| SCHEMBL24633513 | 0.72 | SMN1; SMN2 (0.60) | BCHEKDM4EALDH1A1LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019165043-A2 | INDANE-AMINES AS PD-L1 ANTAGONISTS | CHEMOCENTRYX, INC. (US) | 2019-08-29 | — | — | WO | disclosed |