Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PLA2G4A | P47712 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2353448 | 0.84 | CA4 (0.39) | ALDH1A1LMNAMAOAPTGS1LTA4H | |
| SCHEMBL11770115 | 0.80 | CA4 (0.39) | ALDH1A1LMNAMAOAPTGS1LTA4H | |
| Tromethamine SCHEMBL5081876 | 0.78 | KDM4E (0.44) | KDM4EPOLBPLA2G4AALDH1A1LMNA | |
| SCHEMBL5080405 | 0.77 | CA4 (0.36) | POLBALDH1A1LMNALTA4H | |
| SCHEMBL7200840 | 0.72 | MAOB (0.37) | KDM4EALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL8956762 | 0.71 | HPGD (0.35) | KDM4EALDH1A1LMNAKMT2ALTA4H | |
| SCHEMBL28080380 | 0.71 | ALDH1A1 (0.40) | KDM4EPOLBALDH1A1LMNAMEN1 | |
| Alcohol SCHEMBL29217393 | 0.70 | ALDH1A1 (0.43) | ALDH1A1LMNARECQLLTA4H | |
| SCHEMBL358205 | 0.69 | CA4 (0.39) | ALDH1A1LMNAMAOAPTGS1LTA4H | |
| Tromethamine SCHEMBL18128299 | 0.69 | ALDH1A1 (0.46) | KDM4EPOLBALDH1A1S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3630871-B1 | SPORTS EQUIPMENT COMPRISING SILICONE POLYCARBONATE ELASTOMER | SHPP GLOBAL TECH BV (NL) | 2024-03-13 | — | — | EP | disclosed |
| US-20200197755-A1 | SPORTS EQUIPMENT COMPRISING SILICONE POLYCARBONATE ELASTOMER | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2020-06-25 | — | — | US | disclosed |
| US-10618223-B2 | Sacrificial high heat support materials for additive manufacturing processes | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2020-04-14 | — | — | US | disclosed |
| EP-3630871-A1 | SPORTS EQUIPMENT COMPRISING SILICONE POLYCARBONATE ELASTOMER | SABIC Global Technologies B.V. (NL) | 2020-04-08 | — | — | EP | disclosed |
| EP-3509817-B1 | SACRIFICIAL HIGH HEAT SUPPORT MATERIALS FOR ADDITIVE MANUFACTURING PROCESSES | SABIC GLOBAL TECHNOLOGIES BV (NL) | 2020-03-18 | — | — | EP | disclosed |
| EP-3246363-B1 | POLYIMIDE POLYPHENYLSULFONE BLENDS WITH IMPROVED FLAME RESISTANCE | SABIC GLOBAL TECHNOLOGIES BV (NL) | 2019-11-20 | — | — | EP | disclosed |
| US-20190193336-A1 | SACRIFICIAL HIGH HEAT SUPPORT MATERIALS FOR ADDITIVE MANUFACTURING PROCESSES | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2019-06-27 | — | — | US | disclosed |
| EP-2630192-B1 | POLYIMIDE POLYPHENYLSULFONE BLENDS WITH IMPROVED FLAME RESISTANCE | SABIC GLOBAL TECHNOLOGIES BV (NL) | 2019-01-09 | — | — | EP | disclosed |
| EP-2773686-B1 | STEAM PURIFICATION OF POLYIMIDE RESINS | SABIC GLOBAL TECHNOLOGIES BV (NL) | 2018-12-05 | — | — | EP | disclosed |
| WO-2018217507-A1 | SPORTS EQUIPMENT COMPRISING SILICONE POLYCARBONATE ELASTOMER | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2018-11-29 | — | — | WO | disclosed |
| US-4737547-A | (HOMO-OR CO-)POLYMERS OF ETHYLENE WITH COPOLYMERS OF POLYETHYLENE | DU PONT CANADA INC. (CA) | 1988-04-12 | — | — | US | disclosed |
| US-4678834-A | BLOW MOLDING FILMS | DU PONT CANADA INC. (CA) | 1987-07-07 | — | — | US | disclosed |
| EP-0217585-A2 | Manufacture of film from linear low density polyethylene | Du Pont Canada Inc. (CA) | 1987-04-08 | — | — | EP | disclosed |
| EP-0210307-A1 | Process for the grafting of monomers onto polyolefins | Du Pont Canada Inc. (CA) | 1987-02-04 | — | — | EP | disclosed |
| EP-0210306-A2 | Blends of polyolefins with polymers containing reactive agents | Du Pont Canada Inc. (CA) | 1987-02-04 | — | — | EP | disclosed |
| US-4612155-A | ETHYLENE COPOLYMERS GRAFTED WITH UNSATURATED MONOMERS | DU PONT CANADA INC. (CA) | 1986-09-16 | — | — | US | disclosed |
| US-4600740-A | Hindered dydroxybenzyl hexaalkyldiphenyl-methanes and stabilized compositions | ICI AMERICAS INC. (US) | 1986-07-15 | — | — | US | disclosed |
| EP-0172650-A2 | Polyolefin blends containing reactive agents | Du Pont Canada Inc. (CA) | 1986-02-26 | — | — | EP | disclosed |
| US-4526916-A | Polyethylene, bis(tert-alkylperoxyalkyl)benzene, trialkyl isocyanurate, 1,2-polybutadiene, hindered phenol and phosphite antioxidants | DU PONT CANADA INC. (CA) | 1985-07-02 | — | — | US | disclosed |
| EP-0087210-A1 | A rotational moulding process using polyethylene compositions | Du Pont Canada Inc. (CA) | 1983-08-31 | — | — | EP | disclosed |