SCHEMBL21314975

SCHEMBL21314975

COC(=O)c1cn(CCC(F)(F)F)cn1

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
GRM2 Q14416 1/20 0.39
SCD O00767 1/20 0.37
ADAMTS5 Q9UNA0 2/20 0.36
KCNH2 Q12809 2/20 0.34
MAPK1 P28482 1/20 0.34
NOTUM Q6P988 2/20 0.33
SMYD3 Q9H7B4 1/20 0.33
SYK P43405 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
SLC6A9 P48067 1/20 0.33
SLC6A5 Q9Y345 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31332879 0.85 MEN1 (0.42) MEN1KMT2AGRM2SCDADAMTS5
SCHEMBL30323016 0.81 PLA2G4A (0.36)
SCHEMBL2282033 0.81 CPB2 (0.45) MEN1KMT2AGRM2ADAMTS5KCNH2
SCHEMBL15775548 0.80 MEN1 (0.43) MEN1KMT2AGRM2ADAMTS5KCNH2
SCHEMBL21361934 0.80 MEN1 (0.43) MEN1KMT2AGRM2ADAMTS5KCNH2
SCHEMBL20139133 0.79 MEN1 (0.42) MEN1KMT2AGRM2ADAMTS5KCNH2
SCHEMBL26813648 0.79 CPB2 (0.42) MEN1KMT2AGRM2ADAMTS5KCNH2
SCHEMBL26813651 0.79 CPB2 (0.45) MEN1KMT2AGRM2ADAMTS5SMYD3
SCHEMBL7425205 0.78 SMYD3 (0.50) MEN1KMT2AGRM2ADAMTS5MAPK1
SCHEMBL28579686 0.78 MEN1 (0.41) MEN1KMT2AGRM2ADAMTS5KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240376085-A1 BENZIMIDAZOLES AS MODULATORS OF IL-17 JANSSEN PHARMACEUTICA NV (BE) 2024-11-14 US disclosed
CN-113994970-A Substituted sulfonamides for combating animal pests 拜耳公司 2022-02-01 CN disclosed
EP-3534709-B1 SUBSTITUTED SULFONYLAMIDE FOR COMBATING ANIMAL PESTS BAYER AG (DE) 2021-06-16 EP disclosed
EP-3534709-B1 SUBSTITUTED SULFONYLAMIDE FOR COMBATING ANIMAL PESTS BAYER AG (DE) 2021-06-16 EP disclosed
US-10820591-B2 Substituted sulfonyl amides for controlling animal pests BAYER AKTIENGESELLSCHAFT (DE) 2020-11-03 US disclosed
US-10820591-B2 Substituted sulfonyl amides for controlling animal pests BAYER AKTIENGESELLSCHAFT (DE) 2020-11-03 US disclosed
EP-3534709-A1 SUBSTITUTED SULFONYL AMIDES FOR CONTROLLING ANIMAL PESTS Bayer Aktiengesellschaft (DE) 2019-09-11 EP disclosed
US-20190269134-A1 SUBSTITUTED SULFONYL AMIDES FOR CONTROLLING ANIMAL PESTS BAYER AKTIENGESELLSCHAFT (DE) 2019-09-05 US disclosed
US-20190269134-A1 SUBSTITUTED SULFONYL AMIDES FOR CONTROLLING ANIMAL PESTS BAYER AKTIENGESELLSCHAFT (DE) 2019-09-05 US disclosed
CN-110191639-A Substituted sulfonamides for combating animal pests 拜耳公司 2019-08-30 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190269134-A1 SUBSTITUTED SULFONYL AMIDES FOR CONTROLLING ANIMAL PESTS MLYCD, STOM, DDT MEN1 878/4885KMT2A 380/4885GRM2 283/4885
US-10820591-B2 Substituted sulfonyl amides for controlling animal pests MLYCD, STOM, DDT MEN1 878/4885KMT2A 380/4885GRM2 283/4885
US-20240376085-A1 BENZIMIDAZOLES AS MODULATORS OF IL-17 IL17A, IL23R, IL4I1 MEN1 1720/4885KMT2A 2647/4885GRM2 3070/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.