Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A7 | Q99884 | 2/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | LSS | P48449 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.40 |
| ▸ | ATXN2 | Q99700 | 3/20 | 0.40 |
| ▸ | MGLL | Q99685 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20107136 | 1.00 | SLC6A7 (0.47) | SLC6A7HRH4HRH3CCNCCDK8 | |
| SCHEMBL16962831 | 1.00 | SLC6A7 (0.47) | SLC6A7HRH4HRH3CCNCCDK8 | |
| SCHEMBL16962830 | 1.00 | SLC6A7 (0.47) | SLC6A7HRH4HRH3CCNCCDK8 | |
| SCHEMBL16759896 | 0.93 | CCNC (0.41) | SLC6A7CCNCCDK8LSSHPGD | |
| SCHEMBL22911164 | 0.93 | CCNC (0.41) | SLC6A7CCNCCDK8LSSHPGD | |
| SCHEMBL20101593 | 0.89 | CHRNB2 (0.49) | SLC6A7LSSHPGDHTR2BATXN2 | |
| SCHEMBL16759821 | 0.86 | SLC6A7 (0.45) | SLC6A7CCNCCDK8HPGDHTR2B | |
| SCHEMBL16963872 | 0.84 | ATXN2 (0.41) | HPGDENPP2ATXN2 | |
| SCHEMBL16962810 | 0.84 | ATXN2 (0.41) | HPGDENPP2ATXN2 | |
| SCHEMBL22911158 | 0.84 | ENPP2 (0.38) | SLC6A7CCNCCDK8LSSHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900669-B1 | HEXAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AND RELATED COMPOUNDS AS AUTOTAXIN (ATX) INHIBITORS AND AS INHIBITORS OF THE LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION FOR TREATING E.G. RENAL DISEASES | HOFFMANN LA ROCHE (CH) | 2019-09-04 | — | — | EP | disclosed |